Differences in total and high density lipoprotein cholesterol reduction between healthy overweight people with and without signs of fatty liver

Vija Siliņa; Mesfin K. Tessma; Pēteris Tretjakovs; Gita Krievina; Ilze Jākobsone; Guntis Bahs

Abstract

Background

Motivating clinically healthy overweight and obeseindividuals to bring lifestyle behavioural changes prior to an apparent diseaseis still a challenge in primary care. Finding out and discussing anycardiovascular diseases risk associated changes, e.g., fatty liver can be usedas an argument to start lifestyle changes to improve serum lipid level spectrum.

Objective

To find out, if there are any total cholesterol (TC), highdensity lipoprotein cholesterol (HDLC) and TC/HDLC ratio changes within a yearafter consulting healthy overweight people with and without signs of fattyliver.

Methods:

A prospective observational study in Riga, Latvia included118 clinically healthy individuals having body mass index ≥25 m²/kgand below 40 m²/kg and in age group 30-45 that visited primary carephysician. Individuals were tested and consulted for fatty liver and wereadvised to start lifestyle changes to improve lipid levels and to decreaseweight and waist circumference by at least 5 % within one year. Using a pairedt test, we estimated TC, HDLC and TC/HDLC ratio differences in all individualsand between two groups: those with fatty liver (n=44) and without fatty liver(n=74).

Results

A statistically significant paired mean difference wasobserved regarding TC/HDLC ratio reduction in the whole group (0.19, 95% CI0.07, 0.31; p=0.003), as well as, in the group where fatty liver was found(0.27, 95% CI 0.37, 0.50; p=0.024).

We found that in the whole group TC levels decreased(ME=0.92; SE=0.064) and HDLC levels increased (ME=0.09; SE=0.51), however thedifference was not significant, and the same we found by dividing individualsinto subgroups regarding presence of fatty liver.

Conclusions

Our study showed there are positive changes in TC,HDLC and statistically significant changes in TC/HDLC ratio levels after oneyear in clinically healthy overweight and obese individuals residing in Riga,Latvia, especially in those who are aware of having fatty liver.

Points of discussion

Further research is required to set indicators, whenbehavioural changes should be definitely started, and to understand what couldbe the best motivation for behavioural changes in clinically healthy overweightand obese individuals.

Original language	English
Pages	128-129
Number of pages	2
Publication status	Published - 2015
Event	19th Nordic Congress of General Practice (NCGP): Sustainable healthcare through general practice - Svenska Mässan, Gothenburg, Sweden Duration: 16 Jun 2015 → 18 Jun 2015 Conference number: 19 https://www.nfgp.org/flx/nordic_congress/previous_congresses/

Congress

Congress	19th Nordic Congress of General Practice (NCGP)
Abbreviated title	NCGP 2015
Country/Territory	Sweden
City	Gothenburg
Period	16/06/15 → 18/06/15
Internet address	https://www.nfgp.org/flx/nordic_congress/previous_congresses/

Keywords*

Overweight
Obesity

Field of Science*

3.2 Clinical medicine

Publication Type*

3.4. Other publications in conference proceedings (including local)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@conference{60695c5cb13e43e889141bc64caf75e6,

title = "Differences in total and high density lipoprotein cholesterol reduction between healthy overweight people with and without signs of fatty liver",

abstract = "BackgroundMotivating clinically healthy overweight and obeseindividuals to bring lifestyle behavioural changes prior to an apparent diseaseis still a challenge in primary care. Finding out and discussing anycardiovascular diseases risk associated changes, e.g., fatty liver can be usedas an argument to start lifestyle changes to improve serum lipid level spectrum. ObjectiveTo find out, if there are any total cholesterol (TC), highdensity lipoprotein cholesterol (HDLC) and TC/HDLC ratio changes within a yearafter consulting healthy overweight people with and without signs of fattyliver. Methods:A prospective observational study in Riga, Latvia included118 clinically healthy individuals having body mass index ≥25 m2/kgand below 40 m2/kg and in age group 30-45 that visited primary carephysician. Individuals were tested and consulted for fatty liver and wereadvised to start lifestyle changes to improve lipid levels and to decreaseweight and waist circumference by at least 5 % within one year. Using a pairedt test, we estimated TC, HDLC and TC/HDLC ratio differences in all individualsand between two groups: those with fatty liver (n=44) and without fatty liver(n=74). ResultsA statistically significant paired mean difference wasobserved regarding TC/HDLC ratio reduction in the whole group (0.19, 95% CI0.07, 0.31; p=0.003), as well as, in the group where fatty liver was found(0.27, 95% CI 0.37, 0.50; p=0.024). We found that in the whole group TC levels decreased(ME=0.92; SE=0.064) and HDLC levels increased (ME=0.09; SE=0.51), however thedifference was not significant, and the same we found by dividing individualsinto subgroups regarding presence of fatty liver. ConclusionsOur study showed there are positive changes in TC,HDLC and statistically significant changes in TC/HDLC ratio levels after oneyear in clinically healthy overweight and obese individuals residing in Riga,Latvia, especially in those who are aware of having fatty liver. Points of discussionFurther research is required to set indicators, whenbehavioural changes should be definitely started, and to understand what couldbe the best motivation for behavioural changes in clinically healthy overweightand obese individuals. ",

keywords = "Overweight, Obesity",

author = "Vija Siliņa and Tessma, {Mesfin K.} and Pēteris Tretjakovs and Gita Krievina and Ilze Jākobsone and Guntis Bahs",

note = "Affiliations: Vija Silina1,5, Mesfin K.Tessma 2, Peteris Tretjakovs 3,4, Gita Krievina 3,4, Ilze Jakobsone 5, Guntis Bahs 6 1Riga Stradins University, Department of Family Medicine 2KarolinskaInstitutet, Department of Learning, Informatics, Management and Ethics 3Riga Stradins University, Department of Human Physiology and Biochemistry 4Latvia University, Institute of Experimental and Clinical Medicine 5Private primary care practice 6Riga Stradins University, Department of Internal Diseases; 19th Nordic Congress of General Practice (NCGP) : Sustainable healthcare through general practice, NCGP 2015 ; Conference date: 16-06-2015 Through 18-06-2015",

year = "2015",

language = "English",

pages = "128--129",

url = "https://www.nfgp.org/flx/nordic_congress/previous_congresses/",

}

Differences in total and high density lipoprotein cholesterol reduction between healthy overweight people with and without signs of fatty liver. / Siliņa, Vija; Tessma, Mesfin K.; Tretjakovs, Pēteris et al.
2015. 128-129 Abstract from 19th Nordic Congress of General Practice (NCGP), Gothenburg, Sweden.

Research output: Contribution to conference › Abstract › peer-review

TY - CONF

T1 - Differences in total and high density lipoprotein cholesterol reduction between healthy overweight people with and without signs of fatty liver

AU - Siliņa, Vija

AU - Tessma, Mesfin K.

AU - Tretjakovs, Pēteris

AU - Krievina, Gita

AU - Jākobsone, Ilze

AU - Bahs, Guntis

N1 - Conference code: 19

PY - 2015

Y1 - 2015

N2 - BackgroundMotivating clinically healthy overweight and obeseindividuals to bring lifestyle behavioural changes prior to an apparent diseaseis still a challenge in primary care. Finding out and discussing anycardiovascular diseases risk associated changes, e.g., fatty liver can be usedas an argument to start lifestyle changes to improve serum lipid level spectrum. ObjectiveTo find out, if there are any total cholesterol (TC), highdensity lipoprotein cholesterol (HDLC) and TC/HDLC ratio changes within a yearafter consulting healthy overweight people with and without signs of fattyliver. Methods:A prospective observational study in Riga, Latvia included118 clinically healthy individuals having body mass index ≥25 m2/kgand below 40 m2/kg and in age group 30-45 that visited primary carephysician. Individuals were tested and consulted for fatty liver and wereadvised to start lifestyle changes to improve lipid levels and to decreaseweight and waist circumference by at least 5 % within one year. Using a pairedt test, we estimated TC, HDLC and TC/HDLC ratio differences in all individualsand between two groups: those with fatty liver (n=44) and without fatty liver(n=74). ResultsA statistically significant paired mean difference wasobserved regarding TC/HDLC ratio reduction in the whole group (0.19, 95% CI0.07, 0.31; p=0.003), as well as, in the group where fatty liver was found(0.27, 95% CI 0.37, 0.50; p=0.024). We found that in the whole group TC levels decreased(ME=0.92; SE=0.064) and HDLC levels increased (ME=0.09; SE=0.51), however thedifference was not significant, and the same we found by dividing individualsinto subgroups regarding presence of fatty liver. ConclusionsOur study showed there are positive changes in TC,HDLC and statistically significant changes in TC/HDLC ratio levels after oneyear in clinically healthy overweight and obese individuals residing in Riga,Latvia, especially in those who are aware of having fatty liver. Points of discussionFurther research is required to set indicators, whenbehavioural changes should be definitely started, and to understand what couldbe the best motivation for behavioural changes in clinically healthy overweightand obese individuals.

AB - BackgroundMotivating clinically healthy overweight and obeseindividuals to bring lifestyle behavioural changes prior to an apparent diseaseis still a challenge in primary care. Finding out and discussing anycardiovascular diseases risk associated changes, e.g., fatty liver can be usedas an argument to start lifestyle changes to improve serum lipid level spectrum. ObjectiveTo find out, if there are any total cholesterol (TC), highdensity lipoprotein cholesterol (HDLC) and TC/HDLC ratio changes within a yearafter consulting healthy overweight people with and without signs of fattyliver. Methods:A prospective observational study in Riga, Latvia included118 clinically healthy individuals having body mass index ≥25 m2/kgand below 40 m2/kg and in age group 30-45 that visited primary carephysician. Individuals were tested and consulted for fatty liver and wereadvised to start lifestyle changes to improve lipid levels and to decreaseweight and waist circumference by at least 5 % within one year. Using a pairedt test, we estimated TC, HDLC and TC/HDLC ratio differences in all individualsand between two groups: those with fatty liver (n=44) and without fatty liver(n=74). ResultsA statistically significant paired mean difference wasobserved regarding TC/HDLC ratio reduction in the whole group (0.19, 95% CI0.07, 0.31; p=0.003), as well as, in the group where fatty liver was found(0.27, 95% CI 0.37, 0.50; p=0.024). We found that in the whole group TC levels decreased(ME=0.92; SE=0.064) and HDLC levels increased (ME=0.09; SE=0.51), however thedifference was not significant, and the same we found by dividing individualsinto subgroups regarding presence of fatty liver. ConclusionsOur study showed there are positive changes in TC,HDLC and statistically significant changes in TC/HDLC ratio levels after oneyear in clinically healthy overweight and obese individuals residing in Riga,Latvia, especially in those who are aware of having fatty liver. Points of discussionFurther research is required to set indicators, whenbehavioural changes should be definitely started, and to understand what couldbe the best motivation for behavioural changes in clinically healthy overweightand obese individuals.

KW - Overweight

KW - Obesity

M3 - Abstract

SP - 128

EP - 129

T2 - 19th Nordic Congress of General Practice (NCGP)

Y2 - 16 June 2015 through 18 June 2015

ER -