Differences in total and high density lipoprotein cholesterol reduction between healthy overweight people with and without signs of fatty liver

Vija Siliņa, Mesfin K. Tessma, Pēteris Tretjakovs, Gita Krievina, Ilze Jākobsone, Guntis Bahs

Research output: Contribution to conferenceAbstractpeer-review



Motivating clinically healthy overweight and obeseindividuals to bring lifestyle behavioural changes prior to an apparent diseaseis still a challenge in primary care. Finding out and discussing anycardiovascular diseases risk associated changes, e.g., fatty liver can be usedas an argument to start lifestyle changes to improve serum lipid level spectrum.


To find out, if there are any total cholesterol (TC), highdensity lipoprotein cholesterol (HDLC) and TC/HDLC ratio changes within a yearafter consulting healthy overweight people with and without signs of fattyliver.


A prospective observational study in Riga, Latvia included118 clinically healthy individuals  having body mass index ≥25 m2/kgand below 40 m2/kg and in age group 30-45 that visited primary carephysician. Individuals were tested and consulted for fatty liver and wereadvised to start lifestyle changes to improve lipid levels and to decreaseweight and waist circumference by at least 5 % within one year. Using a pairedt test, we estimated TC, HDLC and TC/HDLC ratio differences in all individualsand between two groups: those with fatty liver (n=44) and without fatty liver(n=74).


A statistically significant paired mean difference wasobserved regarding TC/HDLC ratio reduction in the whole group (0.19, 95% CI0.07, 0.31; p=0.003), as well as, in the group where fatty liver was found(0.27, 95% CI 0.37, 0.50; p=0.024).

 We found that in the whole group TC levels decreased(ME=0.92; SE=0.064) and HDLC levels increased (ME=0.09; SE=0.51), however thedifference was not significant, and the same we found by dividing individualsinto subgroups regarding presence of fatty liver.


Our study showed there are positive changes in TC,HDLC and statistically significant changes in TC/HDLC ratio levels after oneyear in clinically healthy overweight and obese individuals residing in Riga,Latvia, especially in those who are aware of having fatty liver.

 Points of discussion

Further research is required to set indicators, whenbehavioural changes should be definitely started, and to understand what couldbe the best motivation for behavioural changes in clinically healthy overweightand obese individuals. 

Original languageEnglish
Number of pages2
Publication statusPublished - 2015
Event19th Nordic Congress of General Practice (NCGP): Sustainable healthcare through general practice - Svenska Mässan, Gothenburg, Sweden
Duration: 16 Jun 201518 Jun 2015
Conference number: 19


Congress19th Nordic Congress of General Practice (NCGP)
Abbreviated titleNCGP 2015
Internet address


  • Overweight
  • Obesity

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


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