Dihydropyridine derivatives as bioprotectors

Gunars Duburs, Brigita Vigante, Aiva Plotniece, Aivars Krauze, Arkadijs Sobolevs, Janina Briede, Vija Klusa, Astrida Velena

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


Depending on the chemical structure peculiarities 1, 4-dihydropyridines possess electron/hydrogen donor, peptide type and lipid-like characteristics and many regulatory activities: neuro- and radio- protection, anti-mutagenic, antidiabetic, anti-inflammatory, anti-ischaemic/anti-anginal and anti-hypertensive actions, as well as growth stimulating and gene transaction properties. These effects appear mostly in low concentrations/doses and show a long-term manifestation. Green chemistry approaches and chemoenzymatic transformations have been used for synthesis of novel bioprotective compounds. This mini-review comprises mainly the data obtained at the Latvian Institute of Organic Synthesis.

Original languageEnglish
Pages (from-to)68-70
Number of pages3
JournalChimica Oggi
Issue number2
Publication statusPublished - Mar 2008
Externally publishedYes

Field of Science*

  • 1.4 Chemical sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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