DIMA 3.0: Domain interaction map

Qibin Luo, Philipp Pagel, Baiba Vilne, Dmitrij Frishman

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Domain Interaction MAp (DIMA, available at http:// webclu.bio.wzw.tum.de/ dima) is a database of predicted and known interactions between protein domains. It integrates 5807 structurally known interactions imported from the iPfam and 3did databases and 46 900 domain interactions predicted by four computational methods: domain phylogenetic profiling, domain pair exclusion algorithm correlated mutations and domain interaction prediction in a discriminative way. Additionally predictions are filtered to exclude those domain pairs that are reported as non-interacting by the Negatome database. The DIMA Web site allows to calculate domain interaction networks either for a domain of interest or for entire organisms, and to explore them interactively using the Flash-based Cytoscape Web software.

Original languageEnglish
Pages (from-to)D724-D729
Number of pages6
JournalNucleic Acids Research
Volume39
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Field of Science

  • 1.6 Biological sciences
  • 2.2 Electrical engineering, Electronic engineering, Information engineering

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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