Disbalance of the T-lymphocyte subpopulation in psoriasis patients and its immune correction

A. J. Rubins, A. L. Mashkilleysson, A. G. Merson, N. M. Gipsh

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the levels of T-lymphocytes and their subpopulations: T-helper cells (T(H)) and T-suppressor cells (T(S)), in the peripheral blood of 57 patients suffering from various clinical forms of psoriasis. Considerable decrease of the T(H)/T(S) rate (0.2 to 1.2) was found in 29 patients (15 with vulgar, 8 with arthropatic, and 6 with exudative psoriasis). The total number of T-lymphocytes was normal in 20 of these patients. In 8 patients showing a marked disbalance of T(H) and T(S) immunomodulators, thymalin and natrii nucleinas were included in the complex schedule of antipsoriatic therapy. As a result of the immunocorrective therapy, the disbalance normalized in 6 cases accompanied by regression of the psoriatic rash. The disbalance of T(H) and T(S) in the peripheral blood of the patients has a certain pathogenic significance in the development of psoriasis, and immunocorrection becomes necessary for successful therapy in severer forms of the disease.

Translated title of the contributionDisbalance of the T-lymphocyte subpopulation in psoriasis patients and its immune correction
Original languageGerman
Pages (from-to)497-501
Number of pages5
JournalH+G Zeitschrift fur Hautkrankheiten
Volume62
Issue number6
Publication statusPublished - 1987
Externally publishedYes

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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