Disease-Targeted Physical Activity Programme as a Therapeutic Strategy for Fibromyalgia: Pilot Study

Objectives*
The study aims to evaluate the efficacy of a disease-targeted physical activity program in alleviating FM symptoms. Key outcomes include changes in the Widespread Pain Index (WPI) and Symptom Severity (SS) scale, with biomarker analyses to follow upon study completion.
Materials and Methods
Twenty-eight FM patients (aged 18–60) were enrolled and divided into two groups: a control group and an intervention group participating in an 8-week, disease-targeted physical activity program. This regimen features simplified yoga-based exercises, customized to patient subgroups based on symptom severity and physical capacity, performed three times weekly. Mid-intervention (week 4) and post-intervention (week 8) clinical assessments were conducted.
Results
Mid-term analyses show a statistically significant improvement in WPI and SS scores among the intervention group compared to the control group, indicating enhanced symptom management and improved quality of life. No adverse events were reported. Biomarker analysis is underway to further elucidate the physiological effects of the intervention.
Conclusions
These promising mid-term results highlight the potential of a disease-targeted physical activity program as a safe and effective therapeutic option for FM patients. This approach not only improves clinical outcomes but also offers an opportunity to deepen our understanding of the underlying pathophysiology of fibromyalgia through
biomarker analysis. Furthermore, a parallel study conducted on patients with Crohn’s disease has demonstrated similar clinical benefits, including improved symptom scores and a reduction in Calprotectin levels, reinforcing the broader applicability of this therapeutic strategy across chronic inflammatory conditions. Final findings will provide valuable insights into tailored, evidence-based interventions.