Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen

Andrejs Šitovs; Katarīna Gurkina; Līga Pētersone; Valentyn Mohylyuk

Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen

Andrejs Šitovs (Corresponding Author)
, Katarīna Gurkina
, Līga Pētersone
, Valentyn Mohylyuk (Corresponding Author)

Lead Researcher Group

Research output: Contribution to conference › Poster

2 Downloads (Pure)

Abstract

Currently, dissolution-permeation testing is mostly applied to poorly soluble
drugs. Few systems are commercially available, each with its own advantages and limitations. To overcome the limitations of existing dissolution-permeation testing systems, we proposed integrating a Ussing (permeability) chamber into the compendial USP II dissolution apparatus. A prototype system using a PAMPA membrane was assembled and tested with the BCS class II drug naproxen. The permeability values obtained were comparable to those reported in the literature.

Original language	English
Number of pages	2
Publication status	Published - 23 Mar 2026
Event	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - Prague Congress Centre, Prague, Czech Republic Duration: 23 Mar 2026 → 26 Mar 2026 Conference number: 15 https://worldmeeting.org/

Meeting

Meeting	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Abbreviated title	PBP World meeting
Country/Territory	Czech Republic
City	Prague
Period	23/03/26 → 26/03/26
Internet address	https://worldmeeting.org/

Keywords*

dissolution
permeability
biopharmaceutical properties
naproxen
BCS

Field of Science*

3.1 Basic medicine
1.4 Chemical sciences

Publication Type*

3.4. Other publications in conference proceedings (including local)

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Dissolution-permeation approach for biopharmaceutical evaluationSubmitted manuscript, 208 KB

Cite this

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title = "Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen",

abstract = "Currently, dissolution-permeation testing is mostly applied to poorly soluble drugs. Few systems are commercially available, each with its own advantages and limitations. To overcome the limitations of existing dissolution-permeation testing systems, we proposed integrating a Ussing (permeability) chamber into the compendial USP II dissolution apparatus. A prototype system using a PAMPA membrane was assembled and tested with the BCS class II drug naproxen. The permeability values obtained were comparable to those reported in the literature.",

keywords = "dissolution, permeability, biopharmaceutical properties, naproxen, BCS",

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Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen. / Šitovs, Andrejs (Corresponding Author); Gurkina, Katarīna ; Pētersone, Līga et al.
2026. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic.

Research output: Contribution to conference › Poster

TY - CONF

T1 - Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen

AU - Šitovs, Andrejs

AU - Gurkina, Katarīna

AU - Pētersone, Līga

AU - Mohylyuk, Valentyn

N1 - Conference code: 15

PY - 2026/3/23

Y1 - 2026/3/23

N2 - Currently, dissolution-permeation testing is mostly applied to poorly soluble drugs. Few systems are commercially available, each with its own advantages and limitations. To overcome the limitations of existing dissolution-permeation testing systems, we proposed integrating a Ussing (permeability) chamber into the compendial USP II dissolution apparatus. A prototype system using a PAMPA membrane was assembled and tested with the BCS class II drug naproxen. The permeability values obtained were comparable to those reported in the literature.

AB - Currently, dissolution-permeation testing is mostly applied to poorly soluble drugs. Few systems are commercially available, each with its own advantages and limitations. To overcome the limitations of existing dissolution-permeation testing systems, we proposed integrating a Ussing (permeability) chamber into the compendial USP II dissolution apparatus. A prototype system using a PAMPA membrane was assembled and tested with the BCS class II drug naproxen. The permeability values obtained were comparable to those reported in the literature.

KW - dissolution

KW - permeability

KW - biopharmaceutical properties

KW - naproxen

KW - BCS

UR - https://worldmeeting.org/

M3 - Poster

T2 - 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Y2 - 23 March 2026 through 26 March 2026

ER -

Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen

Abstract

Meeting

Keywords*

Field of Science*

Publication Type*

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