Do rheumatoid arthritis disease activity, seropositivity and severity predict cerebrovascular events?

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Key word: Rheumatoid arthritis, cerebrovascular disease, stroke, carotid artery intima media thickness
Patients with rheumatoid arthritis (RA) have increased risk of developing cardiovascular disease when compared to the
general population.(Zubieta 2012)
This study investigated whether the atherosclerotic lesions in brachiocephalic vessels, carotid intima-media thickness
(CIMT), cerebrovascular(CV) risk factors and smoking, as well as level of disease activity and severity, seropositivity
are associated with the risk of developing clinical cerebrovascular disease in patients with RA. Therefore a case–control
study was performed within the retrospective cohort of patients with RA. Cases were patients who developed their first
stroke after diagnosis of RA; controls were patients with RA without CVD. Cases and controls had similar RA disease
duration. Traditional and disease-specific risk factors for stroke were collected. The data was analysed using logistic
regression analysis.
Our results showed that cases of stroke were gender independent.
Primary arterial hypertension, non-severe atherosclerotic plaques and older age of patients were associated with stroke
cases in RA patients.
Other traditional and disease specific risk factors, as well as seropositivity, RA disease activity and severity were not
associated with CV events in RA patients in our study
Original languageEnglish
Title of host publicationDaugavpils Universitātes 59. starptautiskās zinātniskās konferences rakstu krājums
Subtitle of host publicationA. DAĻA. DABASZINĀTNES
Place of PublicationDaugavpils
PublisherDaugavpils Universitāte
Number of pages554
ISBN (Print)978-9984-14-832-8
Publication statusPublished - 2017
Event59th International Scientific conference of Daugavpils University - Daugavpils, Latvia
Duration: 6 Apr 20177 Apr 2017
Conference number: 59


Conference59th International Scientific conference of Daugavpils University
OtherDaugavpils Universitātes 59. starptautiskā zinātniskā konference
Internet address


  • rheumatoid arthritis
  • cerebrovascular
  • radiology

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.2. Articles or chapters in other proceedings other than those included in 3.1., with an ISBN or ISSN code


Dive into the research topics of 'Do rheumatoid arthritis disease activity, seropositivity and severity predict cerebrovascular events?'. Together they form a unique fingerprint.

Cite this