Doxycycline pharmacokinetics in geese

Irene Sartini (Coresponding Author), Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Amnart Poapolathep, Andrejs Sitovs, Mario Giorgi

Research output: Contribution to journalArticlepeer-review

Abstract

The study aims to describe the pharmacokinetics of doxycycline after a single intravenous and oral dose (20 mg/kg) in geese. In addition, two multiple-dose simulations have been performed to investigate the predicted plasma concentration after either a 10 or 20 mg/kg daily administration repeated consecutively for 5 days. Ten geese were enrolled in a two-phase cross-over study with a washout period of two weeks. All animals were treated intravenously and orally with doxycycline, and blood samples were collected up to 48 h after drug administration. Sample analysis was performed using a validated HPLC-UV method. A non-compartmental approach was used to evaluate the pharmacokinetic parameters of the drug. A long elimination half-life was observed (13 h). The area under the curve was statistically different between the two treatments, with the oral bioavailability being moderate (43%). The pharmacokinetic/pharmacodynamic index (%T>MIC) during the 48 h treatment period in the present study (71%) suggests that doxycycline appears to have therapeutic efficacy against some Mycoplasma species in the goose. The multiple-dose simulations showed a low accumulation index. A dosage of 10 mg/kg/day for 5 days seemed to be adequate for a good therapeutic efficacy without reaching unnecessarily high plasma concentrations.

Original languageEnglish
JournalJournal of Veterinary Pharmacology and Therapeutics
DOIs
Publication statusAccepted/In press - 2021

Keywords*

  • doxycycline
  • goose
  • in silico
  • pharmacokinetics

Field of Science*

  • 3.1 Basic medicine
  • 4.3 Veterinary science

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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