Drug infiltration in porous hydroxyapatite ceramic and tissue response

L. Berzina-Cimdina, R. Serzane, I. Salma, M. Pilmane, G. Salms, A. Skagers

Research output: Contribution to journalConference articlepeer-review


Sintered porous hydroxyapatite (HAp) ceramics were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), optical and scanning electron microscopy (SEM). The samples were saturated with dexamethasone solution (1 mg/ml) or lidocaine solution (5 mg/ml) using vacuum method. To evaluate early reactogenity of porous synthetic impregnated HAp ceramic implants were inserted in holes of rabbit's lower jaws for 2 weeks, 1 month and 3 months. Immunohistochemical methods for evaluation of growth factors and apoptosis were applied. This study aims to further comprehension of reactogenicity of HAp bioceramic implants as bone substitutes in subperiostal environment.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalIntegrated Ferroelectrics
Issue number1 PART 2
Publication statusPublished - 2008
EventInternational Baltic Sea Region Conference "Functional Materials and Nanotechnologies" (FM&NT-2008) - Institute of Solid State Physics, University of Latvia, Riga, Latvia
Duration: 1 Apr 20084 Apr 2008


  • bioceramics
  • hydrohyapatite
  • implantation
  • porous material

Field of Science*

  • 2.5 Materials engineering
  • 2.4 Chemical engineering
  • 2.6 Medical engineering
  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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