Drug infiltration in porous hydroxyapatite ceramic and tissue response

L. Berzina-Cimdina; R. Serzane; I. Salma; M. Pilmane; G. Salms; A. Skagers

doi:10.1080/10584580802558225

Drug infiltration in porous hydroxyapatite ceramic and tissue response

L. Berzina-Cimdina^*
, R. Serzane
, I. Salma
, M. Pilmane
, G. Salms
, A. Skagers

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

Abstract

Sintered porous hydroxyapatite (HAp) ceramics were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), optical and scanning electron microscopy (SEM). The samples were saturated with dexamethasone solution (1 mg/ml) or lidocaine solution (5 mg/ml) using vacuum method. To evaluate early reactogenity of porous synthetic impregnated HAp ceramic implants were inserted in holes of rabbit's lower jaws for 2 weeks, 1 month and 3 months. Immunohistochemical methods for evaluation of growth factors and apoptosis were applied. This study aims to further comprehension of reactogenicity of HAp bioceramic implants as bone substitutes in subperiostal environment.

Original language	English
Pages (from-to)	66-71
Number of pages	6
Journal	Integrated Ferroelectrics
Volume	103
Issue number	1 PART 2
DOIs	https://doi.org/10.1080/10584580802558225
Publication status	Published - 2008
Event	International Baltic Sea Region Conference "Functional Materials and Nanotechnologies" (FM&NT-2008) - Institute of Solid State Physics, University of Latvia, Riga, Latvia Duration: 1 Apr 2008 → 4 Apr 2008 https://www.cfi.lu.lv/lv/notikumi/konferences/cfiorganizetasstarptautiskaskonferencesunpasakumi/gadskarteja-functional-materials-and-nanotechnologies-konference/fmnt-2008/

Keywords*

bioceramics
hydrohyapatite
implantation
porous material

Field of Science

3.2 Clinical medicine
2.6 Medical engineering
3.1 Basic medicine
2.5 Materials engineering
2.4 Chemical engineering

Publication Type*

3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Control and Systems Engineering
Ceramics and Composites
Condensed Matter Physics
Electrical and Electronic Engineering
Materials Chemistry

Access to Document

10.1080/10584580802558225

Cite this

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title = "Drug infiltration in porous hydroxyapatite ceramic and tissue response",

abstract = "Sintered porous hydroxyapatite (HAp) ceramics were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), optical and scanning electron microscopy (SEM). The samples were saturated with dexamethasone solution (1 mg/ml) or lidocaine solution (5 mg/ml) using vacuum method. To evaluate early reactogenity of porous synthetic impregnated HAp ceramic implants were inserted in holes of rabbit's lower jaws for 2 weeks, 1 month and 3 months. Immunohistochemical methods for evaluation of growth factors and apoptosis were applied. This study aims to further comprehension of reactogenicity of HAp bioceramic implants as bone substitutes in subperiostal environment.",

keywords = "bioceramics, hydrohyapatite, implantation, porous material",

author = "L. Berzina-Cimdina and R. Serzane and I. Salma and M. Pilmane and G. Salms and A. Skagers",

year = "2008",

doi = "10.1080/10584580802558225",

language = "English",

volume = "103",

pages = "66--71",

journal = "Integrated Ferroelectrics",

issn = "1058-4587",

publisher = "Taylor and Francis Ltd.",

number = "1 PART 2",

note = "International Baltic Sea Region Conference {"}Functional Materials and Nanotechnologies{"} (FM\&NT-2008), FM\&NT-2008 ; Conference date: 01-04-2008 Through 04-04-2008",

url = "https://www.cfi.lu.lv/lv/notikumi/konferences/cfiorganizetasstarptautiskaskonferencesunpasakumi/gadskarteja-functional-materials-and-nanotechnologies-konference/fmnt-2008/",

}

TY - JOUR

T1 - Drug infiltration in porous hydroxyapatite ceramic and tissue response

AU - Berzina-Cimdina, L.

AU - Serzane, R.

AU - Salma, I.

AU - Pilmane, M.

AU - Salms, G.

AU - Skagers, A.

PY - 2008

Y1 - 2008

N2 - Sintered porous hydroxyapatite (HAp) ceramics were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), optical and scanning electron microscopy (SEM). The samples were saturated with dexamethasone solution (1 mg/ml) or lidocaine solution (5 mg/ml) using vacuum method. To evaluate early reactogenity of porous synthetic impregnated HAp ceramic implants were inserted in holes of rabbit's lower jaws for 2 weeks, 1 month and 3 months. Immunohistochemical methods for evaluation of growth factors and apoptosis were applied. This study aims to further comprehension of reactogenicity of HAp bioceramic implants as bone substitutes in subperiostal environment.

AB - Sintered porous hydroxyapatite (HAp) ceramics were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), optical and scanning electron microscopy (SEM). The samples were saturated with dexamethasone solution (1 mg/ml) or lidocaine solution (5 mg/ml) using vacuum method. To evaluate early reactogenity of porous synthetic impregnated HAp ceramic implants were inserted in holes of rabbit's lower jaws for 2 weeks, 1 month and 3 months. Immunohistochemical methods for evaluation of growth factors and apoptosis were applied. This study aims to further comprehension of reactogenicity of HAp bioceramic implants as bone substitutes in subperiostal environment.

KW - bioceramics

KW - hydrohyapatite

KW - implantation

KW - porous material

UR - https://www.scopus.com/pages/publications/77958082660

U2 - 10.1080/10584580802558225

DO - 10.1080/10584580802558225

M3 - Conference article

AN - SCOPUS:77958082660

SN - 1058-4587

VL - 103

SP - 66

EP - 71

JO - Integrated Ferroelectrics

JF - Integrated Ferroelectrics

IS - 1 PART 2

T2 - International Baltic Sea Region Conference "Functional Materials and Nanotechnologies" (FM&NT-2008)

Y2 - 1 April 2008 through 4 April 2008

ER -

Drug infiltration in porous hydroxyapatite ceramic and tissue response

Abstract

Keywords*

Field of Science

Publication Type*

ASJC Scopus subject areas

Access to Document

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