Dwell Time on Tableting: Dwell Time According to Force versus Geometric Dwell Time

Valentyn Mohylyuk (Corresponding Author)

Research output: Contribution to journalArticlepeer-review

Abstract

Dwell time is an important parameter responsible for the material deformation and the mechanical and biopharmaceutical properties of the tablet. Thus, it is widely used for scale-up purposes. The geometric dwell time (GDT) can be assumed based on the shape of the punch head and the diameter and speed of the turret. This research is aimed to compare compaction simulator-recorded dwell time according to force (DTF) and the GDT calculated for the simulated rotary tablet press using the microcrystalline cellulose and calcium phosphate mixtures (CEOLUS TM UF-711 and DI-CAFOS® A60) in different proportions. Tablets were prepared, and DTF was analyzed with a compaction simulator (STYL'One Nano and Alix software) upon simulating a small rotary press at 70 rpm and a compression pressure of 10-50 kN (100-500 MPa). While GDT comprised of 14.4 ms, DTF was compression force and formulation dependent. The differences between the DTF values of the formulations decreased as the compression force increased, which was most pronounced at compression forces of 10 and 15 kN.

Original languageEnglish
Pages (from-to)719-726
JournalPharmaceutical Development and Technology
Volume29
Issue number7
Early online date24 Jul 2024
DOIs
Publication statusPublished - Sept 2024

Keywords*

  • Dwell time
  • geometric dwell time
  • dwell time according to force
  • compaction time
  • compaction simulation
  • tableting
  • excipients
  • microcrystalline cellulose
  • calcium phosphate dibasic anhydrous

Field of Science*

  • 2.4 Chemical engineering
  • 2.5 Materials engineering
  • 1.3 Physical sciences
  • 1.4 Chemical sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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