Early Initiation of Continuous Veno-Venous Hemofiltration (CVVH) in sepsis patients may improve long-term survival

Georgijs Moisejevs; Janis Seilis; Armands Pocs; Eva Bormane; Anda Grigane; Dace Trumpika; Regina Baufale; Inara Busmane; Oļegs Šuba; Alise Silova; Linda Gailīte; Girts Brigis

Abstract

Background. Continuous Veno-Venous hemofiltration (CVVH) in the case of sepsis is often used as extracorporeal detoxification method and it is initiated before patients develop absolute indications. So far it is not clear, whether the use of CVVH as the method of detoxification for sepsis patients does influence the indicators of recovery. Aim of study is to describe hazard ratio of CVVH initiation for short-term (7 days) and long-term (28 days) outcomes in sepsis patients.
Methods. A retrospective study of 127 patients who were treated at Riga East Clinical University Hospital’s with diagnosis “sepsis” during the time period from 2014 to 2017 and in whom (CVVH) was used. SPSS software was used to analyze data, and hazard ratio (HR) was calculated using Cox regression method.
Results. Among study patients 47.2% (60/127) were males, median of age 68 years (IQR 58-76). All patients were divided into two groups according to CVVH initiation criteria: 63/124 (49.6%) had absolute indications and 64/124 (50.4%) had relative indications. On the 7th day and on the 28th day of hospital admission survival rates for sepsis patients were 83/127 (65.4%) and 53/127 (41.7%), respectively. During all hospital length of stay survival rate of sepsis patients was 47/127 (37.0%). For the short-term and long-term outcomes initiation of CRRT based on the absolute indications was associated with higher mortality rates HR=2.19 (95%CI=1.17-4.08) and HR=2.08 (95%CI=1.30-3.34), respectively, in comparison to relative indications. After adjustment to other prognostic factors (sepsis origin, need of mechanical lung ventilation, SOFA score, lactate concentration etc.) only long-term higher mortality
rates showed significant association with CRRT initiation based on absolute indications HR=1.96 (95%CI=1.08-3.56).
Conclusions. Early initiation of CVVH in septic patients based on relative indications may improve long-term patient survival.

Original language	English
Pages	28
Number of pages	1
Publication status	Published - Oct 2018
Event	9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management - Vilnius, Lithuania Duration: 25 Oct 2018 → 27 Oct 2018 Conference number: 9 https://healthmanagement.org/c/icu/event/9th-international-baltic-congress-of-anaesthesiology-intensive-care-and-pain-management

Congress

Congress	9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management
Country/Territory	Lithuania
City	Vilnius
Period	25/10/18 → 27/10/18
Internet address	https://healthmanagement.org/c/icu/event/9th-international-baltic-congress-of-anaesthesiology-intensive-care-and-pain-management

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

3.4. Other publications in conference proceedings (including local)

Cite this

Moisejevs, G., Seilis, J., Pocs, A., Bormane, E., Grigane, A., Trumpika, D., Baufale, R., Busmane, I., Šuba, O., Silova, A., Gailīte, L., & Brigis, G. (2018). Early Initiation of Continuous Veno-Venous Hemofiltration (CVVH) in sepsis patients may improve long-term survival. 28. Abstract from 9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management, Vilnius, Lithuania.

@conference{2da1ae1ffb324f84a6f500d5f47b5d23,

title = "Early Initiation of Continuous Veno-Venous Hemofiltration (CVVH) in sepsis patients may improve long-term survival",

abstract = "Background. Continuous Veno-Venous hemofiltration (CVVH) in the case of sepsis is often used as extracorporeal detoxification method and it is initiated before patients develop absolute indications. So far it is not clear, whether the use of CVVH as the method of detoxification for sepsis patients does influence the indicators of recovery. Aim of study is to describe hazard ratio of CVVH initiation for short-term (7 days) and long-term (28 days) outcomes in sepsis patients. Methods. A retrospective study of 127 patients who were treated at Riga East Clinical University Hospital{\textquoteright}s with diagnosis “sepsis” during the time period from 2014 to 2017 and in whom (CVVH) was used. SPSS software was used to analyze data, and hazard ratio (HR) was calculated using Cox regression method.Results. Among study patients 47.2% (60/127) were males, median of age 68 years (IQR 58-76). All patients were divided into two groups according to CVVH initiation criteria: 63/124 (49.6%) had absolute indications and 64/124 (50.4%) had relative indications. On the 7th day and on the 28th day of hospital admission survival rates for sepsis patients were 83/127 (65.4%) and 53/127 (41.7%), respectively. During all hospital length of stay survival rate of sepsis patients was 47/127 (37.0%). For the short-term and long-term outcomes initiation of CRRT based on the absolute indications was associated with higher mortality rates HR=2.19 (95%CI=1.17-4.08) and HR=2.08 (95%CI=1.30-3.34), respectively, in comparison to relative indications. After adjustment to other prognostic factors (sepsis origin, need of mechanical lung ventilation, SOFA score, lactate concentration etc.) only long-term higher mortalityrates showed significant association with CRRT initiation based on absolute indications HR=1.96 (95%CI=1.08-3.56).Conclusions. Early initiation of CVVH in septic patients based on relative indications may improve long-term patient survival.",

author = "Georgijs Moisejevs and Janis Seilis and Armands Pocs and Eva Bormane and Anda Grigane and Dace Trumpika and Regina Baufale and Inara Busmane and Oļegs {\v S}uba and Alise Silova and Linda Gailīte and Girts Brigis",

year = "2018",

month = oct,

language = "English",

pages = "28",

note = "9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management ; Conference date: 25-10-2018 Through 27-10-2018",

url = "https://healthmanagement.org/c/icu/event/9th-international-baltic-congress-of-anaesthesiology-intensive-care-and-pain-management",

}

Moisejevs, G, Seilis, J, Pocs, A, Bormane, E, Grigane, A, Trumpika, D, Baufale, R, Busmane, I, Šuba, O, Silova, A, Gailīte, L & Brigis, G 2018, 'Early Initiation of Continuous Veno-Venous Hemofiltration (CVVH) in sepsis patients may improve long-term survival', 9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management, Vilnius, Lithuania, 25/10/18 - 27/10/18 pp. 28.

Early Initiation of Continuous Veno-Venous Hemofiltration (CVVH) in sepsis patients may improve long-term survival. / Moisejevs, Georgijs; Seilis, Janis; Pocs, Armands et al.
2018. 28 Abstract from 9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management, Vilnius, Lithuania.

Research output: Contribution to conference › Abstract › peer-review

TY - CONF

T1 - Early Initiation of Continuous Veno-Venous Hemofiltration (CVVH) in sepsis patients may improve long-term survival

AU - Moisejevs, Georgijs

AU - Seilis, Janis

AU - Pocs, Armands

AU - Bormane, Eva

AU - Grigane, Anda

AU - Trumpika, Dace

AU - Baufale, Regina

AU - Busmane, Inara

AU - Šuba, Oļegs

AU - Silova, Alise

AU - Gailīte, Linda

AU - Brigis, Girts

N1 - Conference code: 9

PY - 2018/10

Y1 - 2018/10

N2 - Background. Continuous Veno-Venous hemofiltration (CVVH) in the case of sepsis is often used as extracorporeal detoxification method and it is initiated before patients develop absolute indications. So far it is not clear, whether the use of CVVH as the method of detoxification for sepsis patients does influence the indicators of recovery. Aim of study is to describe hazard ratio of CVVH initiation for short-term (7 days) and long-term (28 days) outcomes in sepsis patients. Methods. A retrospective study of 127 patients who were treated at Riga East Clinical University Hospital’s with diagnosis “sepsis” during the time period from 2014 to 2017 and in whom (CVVH) was used. SPSS software was used to analyze data, and hazard ratio (HR) was calculated using Cox regression method.Results. Among study patients 47.2% (60/127) were males, median of age 68 years (IQR 58-76). All patients were divided into two groups according to CVVH initiation criteria: 63/124 (49.6%) had absolute indications and 64/124 (50.4%) had relative indications. On the 7th day and on the 28th day of hospital admission survival rates for sepsis patients were 83/127 (65.4%) and 53/127 (41.7%), respectively. During all hospital length of stay survival rate of sepsis patients was 47/127 (37.0%). For the short-term and long-term outcomes initiation of CRRT based on the absolute indications was associated with higher mortality rates HR=2.19 (95%CI=1.17-4.08) and HR=2.08 (95%CI=1.30-3.34), respectively, in comparison to relative indications. After adjustment to other prognostic factors (sepsis origin, need of mechanical lung ventilation, SOFA score, lactate concentration etc.) only long-term higher mortalityrates showed significant association with CRRT initiation based on absolute indications HR=1.96 (95%CI=1.08-3.56).Conclusions. Early initiation of CVVH in septic patients based on relative indications may improve long-term patient survival.

AB - Background. Continuous Veno-Venous hemofiltration (CVVH) in the case of sepsis is often used as extracorporeal detoxification method and it is initiated before patients develop absolute indications. So far it is not clear, whether the use of CVVH as the method of detoxification for sepsis patients does influence the indicators of recovery. Aim of study is to describe hazard ratio of CVVH initiation for short-term (7 days) and long-term (28 days) outcomes in sepsis patients. Methods. A retrospective study of 127 patients who were treated at Riga East Clinical University Hospital’s with diagnosis “sepsis” during the time period from 2014 to 2017 and in whom (CVVH) was used. SPSS software was used to analyze data, and hazard ratio (HR) was calculated using Cox regression method.Results. Among study patients 47.2% (60/127) were males, median of age 68 years (IQR 58-76). All patients were divided into two groups according to CVVH initiation criteria: 63/124 (49.6%) had absolute indications and 64/124 (50.4%) had relative indications. On the 7th day and on the 28th day of hospital admission survival rates for sepsis patients were 83/127 (65.4%) and 53/127 (41.7%), respectively. During all hospital length of stay survival rate of sepsis patients was 47/127 (37.0%). For the short-term and long-term outcomes initiation of CRRT based on the absolute indications was associated with higher mortality rates HR=2.19 (95%CI=1.17-4.08) and HR=2.08 (95%CI=1.30-3.34), respectively, in comparison to relative indications. After adjustment to other prognostic factors (sepsis origin, need of mechanical lung ventilation, SOFA score, lactate concentration etc.) only long-term higher mortalityrates showed significant association with CRRT initiation based on absolute indications HR=1.96 (95%CI=1.08-3.56).Conclusions. Early initiation of CVVH in septic patients based on relative indications may improve long-term patient survival.

M3 - Abstract

SP - 28

T2 - 9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management

Y2 - 25 October 2018 through 27 October 2018

ER -