Effect of ginkgo extract on eye microcirculation in patients with diabetes

Asta Spadiene, Nijole Savickiene, Nijole Jurgeviciene, Rimantas Zalinkevicius, Antanas Norkus, Rytas Ostrauskas, Andrejs Skesters, Alisa Silova, Hiliaras Rodovicius, Migle Francaite-Daugeliene

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
8 Downloads (Pure)


The prevalence of Diabetes mellitus has increased around the world in the last decade. Anyone with diabetes is at risk of diabetic eye complications. The aim of the study was to compare effects of standardized Ginkgo biloba (Ginkgo biloba L.) dry extract (Ex.Gb) with the placebo on the microcirculation lesions of the eye in randomized double-blind placebo-controlled trial. 44 patients with type 2 diabetes mellitus were randomized to Ex.Gb 160 mg per day or placebo, and were followed up for nine months. Dose of Ex.Gb was increased to 240 mg in next nine months. Total Antioxidant Status (TAS) of plasma was measured using the Trolox equivalent antioxidant capacity assay. Ophthalmologic examination was performed by the biomicroscopic method. Vascular, intravascular and perivascular alterations were evaluated, and total conjunctival index was calculated. Though the values of the total conjunctival index and its constituent decreased (P<0.05) during the study in Ex.Gb group, there were no significant differences between these parameters as compared with placebo group. Evaluation of plasma TAS showed gradually increment, although insignificant and very small, in Ex.Gb group. The significance of Ex.Gb on development of the alterations of eye microcirculation, especially in elder patients needs to be explored further.

Original languageEnglish
Pages (from-to)736-741
Number of pages6
JournalCentral European Journal of Medicine
Issue number6
Publication statusPublished - Dec 2013


  • Antioxidant
  • Diabetic retinopathy
  • Gingko Biloba extract
  • Total conjunctival index

Field of Science*

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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