Effect of inhibiting carnitine biosynthesis on male rat sexual performance

Maija Dambrova, Helena Cirule, Baiba Svalbe, Liga Zvejniece, Osvalds Pugovichs, Tatjana Zorenko, Ivars Kalvinsh, Edgars Liepinsh, Irina Belozertseva

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

l-carnitine has a documented role as a cofactor in cellular energy metabolism and fatty acid β-oxidation pathways and it has also been considered to function in reproductive biology. We investigated whether decreasing concentrations of l-carnitine using an inhibitor of its biosynthesis, mildronate (3-(2,2,2-trimethylhydrazinium)-propionate), would influence the sexual behavior or sperm quality in male rats. Mildronate treatment induced a significant decrease in carnitine concentration and an increase in γ-butyrobetaine (GBB) concentration in both plasma and testes extracts. However, the expression of carnitine palmitoyltransferase I in testes and testosterone concentration in plasma was not changed in mildronate treated rat. Behavioral experiments demonstrated that mildronate treatment did not decrease the sexual motivation in both sexually naive and sexually experienced rats. The densities of spermatozoa in the cauda epididymis, as well as motility, were unchanged after mildronate treatment at a dose of 100 mg/kg. In conclusion, our study provides experimental evidence that mildronate induces decrease in the free carnitine concentration in rat testes, but does not decrease the sexual activity or sperm quality of male rats.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalPhysiology and Behavior
Volume95
Issue number3
DOIs
Publication statusPublished - 20 Oct 2008
Externally publishedYes

Keywords

  • γ-butyrobetaine
  • Carnitine
  • Male rat
  • Mildronate
  • Sexual behavior
  • Sperm
  • Testes

Field of Science

  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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