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Abstract
Objectives. Metabolic syndrome (MetS) includes such factors as obesity, elevated blood pressure, and
distorted lipid- and glucose metabolism. It is well known that psoriasis and the metabolic syndrome separately are risk factors for systemic microvascular dysfunction. The metabolic syndrome has been associated with psoriasis and according to publications psoriatic patients, have at least twice the risk of developing metabolic comorbidities compared with the general population. We aimed to find out whether there is a significant effect on microvascular function in psoriatic patients with and without MetS.
Materials and Methods. MetS factors were analysed for 34 patients (46 ± 12 yr) with moderate to
severe psoriasis vulgaris. MetS was defined using the National Cholesterol Education Program Adult
Treatment Panel III criteria. MetS were positive for 13 patients (MetS group) and negative for 21 patients
(non-MetS group). Blood flow (PU, perfusion units) in psoriatic and normal skin was measured by a
single-channel Laser Doppler blood flowmeter (Blood Flowmeter, ADInstruments Ltd., Oxford, UK). Postocclusive reactive hyperaemia (% changes from basal flow) was assessed on the plaque (psoriatic) and nonplaque (normal) site.
Results. There was no group difference in basal blood flow and postocclusive hyperemia test in psoriatic
skin. However data of normal skin showed statistically lower postocclusive hyperemia in MetS group
compared with non-MetS (5% vs 53%, p < 0.05). In the MetS group, lower postocclusive hyperemia was
statistically significantly correlated with a higher waist circumference (r = -0.408, p < 0.05) and lower
serum levels of HDL (r = -0.526, p < 0.05).
Conclusions. Our data sugests that the pathogenesis of microvascular dysfunction in psoriasis patients
has a complex origin which might involve the interaction between the immune system and several metabolic syndrome factors. Since the underlying mechanisms are still unclear, the study should be continued to find out which of the growth factors and cytokines might have a diagno st ic value.
distorted lipid- and glucose metabolism. It is well known that psoriasis and the metabolic syndrome separately are risk factors for systemic microvascular dysfunction. The metabolic syndrome has been associated with psoriasis and according to publications psoriatic patients, have at least twice the risk of developing metabolic comorbidities compared with the general population. We aimed to find out whether there is a significant effect on microvascular function in psoriatic patients with and without MetS.
Materials and Methods. MetS factors were analysed for 34 patients (46 ± 12 yr) with moderate to
severe psoriasis vulgaris. MetS was defined using the National Cholesterol Education Program Adult
Treatment Panel III criteria. MetS were positive for 13 patients (MetS group) and negative for 21 patients
(non-MetS group). Blood flow (PU, perfusion units) in psoriatic and normal skin was measured by a
single-channel Laser Doppler blood flowmeter (Blood Flowmeter, ADInstruments Ltd., Oxford, UK). Postocclusive reactive hyperaemia (% changes from basal flow) was assessed on the plaque (psoriatic) and nonplaque (normal) site.
Results. There was no group difference in basal blood flow and postocclusive hyperemia test in psoriatic
skin. However data of normal skin showed statistically lower postocclusive hyperemia in MetS group
compared with non-MetS (5% vs 53%, p < 0.05). In the MetS group, lower postocclusive hyperemia was
statistically significantly correlated with a higher waist circumference (r = -0.408, p < 0.05) and lower
serum levels of HDL (r = -0.526, p < 0.05).
Conclusions. Our data sugests that the pathogenesis of microvascular dysfunction in psoriasis patients
has a complex origin which might involve the interaction between the immune system and several metabolic syndrome factors. Since the underlying mechanisms are still unclear, the study should be continued to find out which of the growth factors and cytokines might have a diagno st ic value.
| Original language | English |
|---|---|
| Pages (from-to) | 550 |
| Number of pages | 1 |
| Journal | Medicina (Kaunas) |
| Volume | 59 |
| Issue number | Suppl.2 |
| Publication status | Published - 29 Mar 2023 |
| Event | RSU International Research Conference 2023: Knowledge for Use in Practice - Rīga Stradiņš University & online, Riga, Latvia Duration: 29 Mar 2023 → 31 Mar 2023 https://rw2023.rsu.lv/events/rsu-international-research-conference-knowledge-use-practice https://rw2023.rsu.lv/conferences/knowledge-use-practice |
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
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Effect of Metabolic Syndrome on Microcirculatory Function in Psoriatic Patients
Bondare-Ansberga , V. (Speaker), Miķelsone, I. (Co-author), Jurka, A. (Co-author), Rumaka, M. (Co-author), Trošins, D. (Co-author), Hartmane, I. (Co-author), Blumfelds, L. (Co-author) & Tretjakovs, P. (Co-author)
29 Mar 2023Activity: Talk or presentation types › Poster presentation