Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance

Valentyn Mohylyuk; Kirils Kukuls; Alīna Jaroslava Frolova; Elzbieta Maria Buczkowska; Julia Shmyrova

doi:10.13140/RG.2.2.22897.65124

Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance

Valentyn Mohylyuk^*
, Kirils Kukuls
, Alīna Jaroslava Frolova
, Elzbieta Maria Buczkowska
, Julia Shmyrova

^*Corresponding author for this work

Lead Researcher Group

Research output: Contribution to conference › Poster › peer-review

Original language	English
Number of pages	1
DOIs	https://doi.org/10.13140/RG.2.2.22897.65124
Publication status	Published - 24 Mar 2026
Event	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - Prague Congress Centre, Prague, Czech Republic Duration: 23 Mar 2026 → 26 Mar 2026 Conference number: 15 https://worldmeeting.org/

Meeting

Meeting	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Abbreviated title	PBP World meeting
Country/Territory	Czech Republic
City	Prague
Period	23/03/26 → 26/03/26
Internet address	https://worldmeeting.org/

Keywords*

microcrystalline cellulose
MCC
roll compaction force
mechanical properties
solid dosage forms
oral dosage forms
tablets
high dose
poorly compactible substance
roll compaction

Field of Science

3.1 Basic medicine
2.5 Materials engineering
2.4 Chemical engineering
1.4 Chemical sciences

Publication Type*

3.4. Other publications in conference proceedings (including local)

Access to Document

10.13140/RG.2.2.22897.65124Licence: CC BY

https://www.linkedin.com/posts/asahi-kasei-microcrystalline-cellulose_pbp2026-asahikasei-ceolus-ugcPost-7442462711415906304-xITI?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAPse8kBJBCRW5-Y7uflZsCzGbBDPthVpzw

3 Poster
3 Article
1 Abstract

Effect of Microcrystalline Cellulose (MCC) Grade on the Properties of Twin-Screw Melt Granulated Formulations of Ascorbic Acid
Mohylyuk, V., Ding, Y., Shmyrova, J. & Andrews, G. P., 24 Mar 2025, p. M095.
Research output: Contribution to conference › Poster

Open Access
File

17 Downloads (Pure)
Fingerprints of Distinct Types of Microcrystalline Cellulose (MCC): Does the MCC Type Matter for Tableting?
Mohylyuk, V., Pelloux, A. & Kukuls, K., Sept 2024. 1 p.
Research output: Contribution to conference › Poster
Twin-screw melt granulation with PEG 8000: Effect of binder particle size and processing temperature on the granule and tablet properties
Horváth, Z. M., Petersone, L. & Mohylyuk, V., Sept 2024, In: Advanced Powder Technology. 35, 9, 104585.
Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus)

1 Active
2 Finished

Direct compression of highly used excipients in pharmaceutical tablet manufacturing: calcium phosphate dibasic anhydrous and microcrystalline cellulose
Kukuls, K. (Member of project working group) & Mohylyuk, V. (Project leader)
1/08/23 → 31/07/27
Project: Projects not classified elsewhere › Projects outside institution
Investigation of the effect of microcrystalline cellulose type and roll compaction force on the properties of granules and tablets containing a high dose of poorly compactible substance
Mohylyuk, V. (Project leader) & Kukuls, K. (Member of project working group)
14/10/25 → 28/02/26
Project: Contract works and contract research with companies, public persons, private financing and income from intellectual property › Contract research
CONTRACT No 3-L-9/27/2024 On laboratory trial services
Mohylyuk, V. (Project leader) & Kukuls, K. (Member of project working group)
26/06/24 → 23/08/24
Project: Contract works and contract research with companies, public persons, private financing and income from intellectual property › Contract research

3 Poster presentation
1 Hosting a non-academic visitor
1 Oral presentation
1 Visiting an external non-academic institution

Modern trends in the development of dosage form formulations: a view through the prism of publications by the specific scientific group
Mohylyuk, V. (Speaker)
15 Apr 2026
Activity: Talk or presentation types › Oral presentation
Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance
Mohylyuk, V. (Speaker), Kukuls, K. (Co-author), Frolova, A. J. (Co-author), Buczkowska, E. M. (Co-author) & Shmyrova, J. (Co-author)
23 Mar 2026 → 26 Mar 2026
Activity: Talk or presentation types › Poster presentation
Asahi Kasei Europe GmbH
Mohylyuk, V. (Visiting researcher)
10 Jun 2025
Activity: Visiting an external institution types › Visiting an external non-academic institution

News » Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance
Mohylyuk, V., Kukuls, K., Frolova, A. J., Buczkowska, E. M. & Shmyrova, J.
12/05/26
1 item of Media coverage
Press/Media

Cite this

Mohylyuk, V., Kukuls, K., Frolova, A. J., Buczkowska, E. M., & Shmyrova, J. (2026). Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic. https://doi.org/10.13140/RG.2.2.22897.65124

Mohylyuk, Valentyn ; Kukuls, Kirils ; Frolova, Alīna Jaroslava et al. / Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic.1 p.

@conference{eb815c41088142798131f719d2815821,

title = "Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance",

keywords = "microcrystalline cellulose, MCC, roll compaction force, mechanical properties, solid dosage forms, oral dosage forms, tablets, high dose, poorly compactible substance, roll compaction",

author = "Valentyn Mohylyuk and Kirils Kukuls and Frolova, \{Alīna Jaroslava\} and Buczkowska, \{Elzbieta Maria\} and Julia Shmyrova",

year = "2026",

month = mar,

day = "24",

doi = "10.13140/RG.2.2.22897.65124",

language = "English",

note = "15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, PBP World meeting ; Conference date: 23-03-2026 Through 26-03-2026",

url = "https://worldmeeting.org/",

}

Mohylyuk, V , Kukuls, K, Frolova, AJ, Buczkowska, EM & Shmyrova, J 2026, 'Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance', 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic, 23/03/26 - 26/03/26. https://doi.org/10.13140/RG.2.2.22897.65124

Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance. / Mohylyuk, Valentyn ; Kukuls, Kirils; Frolova, Alīna Jaroslava et al.
2026. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance

AU - Mohylyuk, Valentyn

AU - Kukuls, Kirils

AU - Frolova, Alīna Jaroslava

AU - Buczkowska, Elzbieta Maria

AU - Shmyrova, Julia

N1 - Conference code: 15

PY - 2026/3/24

Y1 - 2026/3/24

KW - microcrystalline cellulose

KW - MCC

KW - roll compaction force

KW - mechanical properties

KW - solid dosage forms

KW - oral dosage forms

KW - tablets

KW - high dose

KW - poorly compactible substance

KW - roll compaction

U2 - 10.13140/RG.2.2.22897.65124

DO - 10.13140/RG.2.2.22897.65124

M3 - Poster

T2 - 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Y2 - 23 March 2026 through 26 March 2026

ER -

Mohylyuk V , Kukuls K, Frolova AJ, Buczkowska EM, Shmyrova J. Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance. 2026. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic. doi: 10.13140/RG.2.2.22897.65124

Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance

Meeting

Keywords*

Field of Science

Publication Type*

Access to Document

Research output

Projects

Activities

Press/Media

Cite this