Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules

Valentyn Mohylyuk; David S. Jones; Shu Li; Yalin Ding; Gavin P. Andrews

doi:10.5920/bjpharm.1160

Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules

Valentyn Mohylyuk, David S. Jones, Shu Li, Yalin Ding, Gavin P. Andrews (Corresponding Author)

Research output: Contribution to journal › Conference article › peer-review

Abstract

The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative simplicity of scale-up and process control. Tablets are the most popular solid dosage form, while batch granulation is one of the most often used technologies in tablet manufacturing. Using ascorbic acid as a model, we show the possibility of producing granules and tablets with a sustained-release profile using three technological operations: mixing, continuous melt-granulation, and tableting.

Original language	English
Article number	1160
Journal	British Journal of Pharmacy
Volume	7
Issue number	2
DOIs	https://doi.org/10.5920/bjpharm.1160
Publication status	Published - 2022
Externally published	Yes
Event	13th Conference of Academy of Pharmaceutical Sciences (APS) - Belfast, United Kingdom Duration: 7 Sept 2022 → 9 Sept 2022 Conference number: 13 https://www.emedevents.com/c/medical-conferences-2022/13th-academy-of-pharmaceutical-sciences-aps-pharmsci-international-conferance-2022

Field of Science*

3.1 Basic medicine

Publication Type*

1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)

Access to Document

10.5920/bjpharm.1160Licence: CC BY

1 Poster

Mechanical properties of tablets: direct compression vs. twin-screw melt granulation with PEG 8000
Mohylyuk, V. (Corresponding Author), Horvath, Z. M., Kukuls, K., Lauberte, L. & Paulausks, A., 21 May 2024. 1 p.
Research output: Contribution to conference › Poster

Open Access

1 Editorial work
1 Poster presentation

Effect of Magnesium Stearate Amount on the Tableting of Spray-dried Grades of Mannitol and Fluid-Bed Granulated Grade of Isomalt
Mohylyuk, V. (Speaker), Kukuls, K. (Co-author), Frolova, A. J. (Co-author), Horvath, Z. M. (Co-author) & Gniazdowska, E. M. (Co-author)
24 Mar 2025 → 25 Mar 2025
Activity: Talk or presentation types › Poster presentation
Pharmaceutics (Journal)
Mohylyuk, V. (Guest Editor)
29 Sept 2024 → 30 Mar 2025
Activity: Publication peer-review and editorial work types › Editorial work

Cite this

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title = "Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules",

abstract = "The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative simplicity of scale-up and process control. Tablets are the most popular solid dosage form, while batch granulation is one of the most often used technologies in tablet manufacturing. Using ascorbic acid as a model, we show the possibility of producing granules and tablets with a sustained-release profile using three technological operations: mixing, continuous melt-granulation, and tableting.",

author = "Valentyn Mohylyuk and Jones, {David S.} and Shu Li and Yalin Ding and Andrews, {Gavin P.}",

year = "2022",

doi = "10.5920/bjpharm.1160",

language = "English",

volume = "7",

journal = "British Journal of Pharmacy",

issn = "2058-8356",

publisher = "University of Huddersfield Press",

number = "2",

note = "13th Conference of Academy of Pharmaceutical Sciences (APS) , PharmSci International Conference 2022 ; Conference date: 07-09-2022 Through 09-09-2022",

url = "https://www.emedevents.com/c/medical-conferences-2022/13th-academy-of-pharmaceutical-sciences-aps-pharmsci-international-conferance-2022",

}

TY - JOUR

T1 - Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules

AU - Mohylyuk, Valentyn

AU - Jones, David S.

AU - Li, Shu

AU - Ding, Yalin

AU - Andrews, Gavin P.

N1 - Conference code: 13

PY - 2022

Y1 - 2022

N2 - The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative simplicity of scale-up and process control. Tablets are the most popular solid dosage form, while batch granulation is one of the most often used technologies in tablet manufacturing. Using ascorbic acid as a model, we show the possibility of producing granules and tablets with a sustained-release profile using three technological operations: mixing, continuous melt-granulation, and tableting.

AB - The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative simplicity of scale-up and process control. Tablets are the most popular solid dosage form, while batch granulation is one of the most often used technologies in tablet manufacturing. Using ascorbic acid as a model, we show the possibility of producing granules and tablets with a sustained-release profile using three technological operations: mixing, continuous melt-granulation, and tableting.

U2 - 10.5920/bjpharm.1160

DO - 10.5920/bjpharm.1160

M3 - Conference article

SN - 2058-8356

VL - 7

JO - British Journal of Pharmacy

JF - British Journal of Pharmacy

IS - 2

M1 - 1160

T2 - 13th Conference of Academy of Pharmaceutical Sciences (APS)

Y2 - 7 September 2022 through 9 September 2022

ER -

Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules

Abstract

Field of Science*

Publication Type*

Access to Document

Fingerprint

Research output

Mechanical properties of tablets: direct compression vs. twin-screw melt granulation with PEG 8000

Activities

Effect of Magnesium Stearate Amount on the Tableting of Spray-dried Grades of Mannitol and Fluid-Bed Granulated Grade of Isomalt

Pharmaceutics (Journal)

Cite this