Effect of the solvent nature on the course of quaternization of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine

K. Pajuste, M. Gosteva, D. Kaldre, M. Plotniece, B. Cekavicus, A. Sobolev, A. Priksane, G. Tirzitis, G. Duburs, A. Plotniece

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The effect of the solvent nature and temperature on the quaternization of 3,5-diethoxycarbonyl-2,6-di- methyl-4-(3-pyridyl)-1,4-dihydropyridine by lipophilic alkyl bromides has been investigated. By comparison of the solvent effect (acetone, acetonitrile, and 2-butanone) on the alkylation of the pyridine fragment of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine it was established that conducting the reaction in acetonitrile at 81 °C is the most optimal.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalChemistry of Heterocyclic Compounds
Volume47
Issue number5
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

Keywords*

  • 1,4-dihydropyridines
  • 2-butanone
  • acetone
  • acetonitrile
  • pyridinium derivatives
  • quaternization of pyridine

Field of Science*

  • 1.4 Chemical sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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