Effect of treatment with proteolytic enzymes on the mechanical properties of xenotransplants

B. A. Purinya; V. A. Kas'yanov; N. K. Bokhua; A. V. Chomakhidze

doi:10.1007/BF00604964

Effect of treatment with proteolytic enzymes on the mechanical properties of xenotransplants

B. A. Purinya
, V. A. Kas'yanov
, N. K. Bokhua
, A. V. Chomakhidze

Research output: Contribution to journal › Article › peer-review

Abstract

1. Treatment of xenotransplants with proteolytic enzymes is a new and promising route which enables substitutes for diseased vessels which are compatible with human tissues to be prepared. 2. Enzyme treatment of arteries permits the collagen elastic carcass of the vessel to be isolated and the main parameters of its mechanical properties to be determined. 3. The method of treatment of bovine common carotid arteries with trypsin does not significantly affect the main parameters of the mechanical properties of their walls which makes it possible to recommend this method for practical application in vascular surgery. 4. The greatest effect on changing the main parameters of the mechanical properties of the vessel is exerted by pepsin, under the action of which the wall of the xenotransplant becomes rigid and of low deformability, which makes it impracticable for use as a substitute.

Original language	English
Pages (from-to)	92-94
Number of pages	3
Journal	Mechanics of Composite Materials
Volume	15
Issue number	1
DOIs	https://doi.org/10.1007/BF00604964
Publication status	Published - Jan 1979
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Field of Science*

3.2 Clinical medicine
2.5 Materials engineering

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1.1. Scientific article indexed in Web of Science and/or Scopus database

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10.1007/BF00604964

Cite this

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title = "Effect of treatment with proteolytic enzymes on the mechanical properties of xenotransplants",

abstract = "1. Treatment of xenotransplants with proteolytic enzymes is a new and promising route which enables substitutes for diseased vessels which are compatible with human tissues to be prepared. 2. Enzyme treatment of arteries permits the collagen elastic carcass of the vessel to be isolated and the main parameters of its mechanical properties to be determined. 3. The method of treatment of bovine common carotid arteries with trypsin does not significantly affect the main parameters of the mechanical properties of their walls which makes it possible to recommend this method for practical application in vascular surgery. 4. The greatest effect on changing the main parameters of the mechanical properties of the vessel is exerted by pepsin, under the action of which the wall of the xenotransplant becomes rigid and of low deformability, which makes it impracticable for use as a substitute.",

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year = "1979",

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doi = "10.1007/BF00604964",

language = "English",

volume = "15",

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journal = "Mechanics of Composite Materials",

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TY - JOUR

T1 - Effect of treatment with proteolytic enzymes on the mechanical properties of xenotransplants

AU - Purinya, B. A.

AU - Kas'yanov, V. A.

AU - Bokhua, N. K.

AU - Chomakhidze, A. V.

PY - 1979/1

Y1 - 1979/1

N2 - 1. Treatment of xenotransplants with proteolytic enzymes is a new and promising route which enables substitutes for diseased vessels which are compatible with human tissues to be prepared. 2. Enzyme treatment of arteries permits the collagen elastic carcass of the vessel to be isolated and the main parameters of its mechanical properties to be determined. 3. The method of treatment of bovine common carotid arteries with trypsin does not significantly affect the main parameters of the mechanical properties of their walls which makes it possible to recommend this method for practical application in vascular surgery. 4. The greatest effect on changing the main parameters of the mechanical properties of the vessel is exerted by pepsin, under the action of which the wall of the xenotransplant becomes rigid and of low deformability, which makes it impracticable for use as a substitute.

AB - 1. Treatment of xenotransplants with proteolytic enzymes is a new and promising route which enables substitutes for diseased vessels which are compatible with human tissues to be prepared. 2. Enzyme treatment of arteries permits the collagen elastic carcass of the vessel to be isolated and the main parameters of its mechanical properties to be determined. 3. The method of treatment of bovine common carotid arteries with trypsin does not significantly affect the main parameters of the mechanical properties of their walls which makes it possible to recommend this method for practical application in vascular surgery. 4. The greatest effect on changing the main parameters of the mechanical properties of the vessel is exerted by pepsin, under the action of which the wall of the xenotransplant becomes rigid and of low deformability, which makes it impracticable for use as a substitute.

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DO - 10.1007/BF00604964

M3 - Article

AN - SCOPUS:34250273178

SN - 0191-5665

VL - 15

SP - 92

EP - 94

JO - Mechanics of Composite Materials

JF - Mechanics of Composite Materials

IS - 1

ER -

Effect of treatment with proteolytic enzymes on the mechanical properties of xenotransplants

Abstract

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