Efficacy of proanthocyanidins from Pelargonium sidoides root extract in reducing P. gingivalis viability while preserving oral commensal S. salivarius

Nijole Savickiene, Aiste Jekabsone, Lina Raudone, Asmaa S. Abdelgeliel, Andrea Cochis, Lia Rimondini, Elina Makarova, Solveiga Grinberga, Osvalds Pugovics, Maija Dambrova, Ingrida M. Pacauskiene, Nomeda Basevičiene, Pranas Viškelis

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Bacterial resistance to antibiotics and the disruption of beneficial microbiota are key problems in contemporary medicine and make the search for new, more efficient infection treatment strategies among the most important tasks in medicine. Multicomponent plant-derived preparations with mild antibacterial activity created by many simultaneous mechanisms together with anti-inflammatory, innate immune and regenerative capacity-stimulating properties are good candidates for this therapy, and proanthocyanidins are among the most promising compounds of this sort. In this study, we have isolated proanthocyanidins from Pelargonium sidoides DC root extract and characterized and compared the composition, antioxidant properties and antibacterial activity of the proanthocyanidin fraction with those of the whole extract. The results revealed that proanthocyanidins had significantly stronger antioxidant capacity compared to the root extract and exhibited a unique antibacterial action profile that selectively targets Gram-negative keystone periodontal and peri-implant pathogenic strains, such as Porphyromonas gingivalis, while preserving the viability of beneficial oral commensal Streptococcus salivarius. The finding suggests that proanthocyanidins from Pelargonium sidoides root extract are good candidates for the prolonged and harmless treatment of infectious diseases.

Original languageEnglish
Article number1499
JournalMaterials
Volume11
Issue number9
DOIs
Publication statusPublished - 22 Aug 2018
Externally publishedYes

Keywords

  • Antioxidant activity
  • Bacteriotoxicity
  • LC/MS/MS
  • Pelargonium sidoides root extract
  • Proanthocyanidins

Field of Science

  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'Efficacy of proanthocyanidins from Pelargonium sidoides root extract in reducing P. gingivalis viability while preserving oral commensal S. salivarius'. Together they form a unique fingerprint.

Cite this