Elevated serum nitrate concentrations in active spondyloarthropathies

D. O. Stichtenoth, J. Wollenhaupt, D. Andersone, H. Zeidler, J. C. Frölich

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We determined the concentrations of nitrate, reflecting endogenous nitric oxide (NO) production, by gas chromatography in the sera of patients with spondyloarthropathy. In those patients with active disease, as indicated by elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) serum nitrate levels (n = 7; mean 73.2±S.D. 21.7 μmol/l) were significantly (P < 0.001) increased in comparison to patients with inactive spondyloarthropathy (n = 7; 31.7±9.5 μmol/l) and healthy volunteers (n = 10; 33.4±15.9μmol/l). The nitrate serum levels correlated closely with CRP and ESR (r = 0.8, P<0.001, each). There were no major differences in dietary nitrate intake between the study groups. The increased concentrations of serum nitrate in patients with active spondyloarthropathy indicate that NO production is enhanced in these patients.

Original languageEnglish
Pages (from-to)616-619
Number of pages4
JournalRheumatology
Volume34
Issue number7
DOIs
Publication statusPublished - Jul 1995
Externally publishedYes

Keywords

  • Arthritis
  • Nitrate
  • Nitric oxide
  • Spondyloarthropathy

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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