Epidemiological and clinical characteristics of adult patients with chronic spontaneous urticaria in Latvia: insights from a two-centre study

Artūrs Sokolovskis (Corresponding Author), Lāsma Lapiņa (Corresponding Author), Anna Lauva, Sindija Papirte, Maksims Zolovs, Līga Ciekure, Egīls Mauliņš, Līga Lielmane, Petra Kriķe, Marija Selicka, Signe Puriņa, Nataļja Kurjāne

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Chronic spontaneous urticaria (CSU) significantly impacts the quality of life of affected individuals. Objectives: This study aimed to elucidate the epidemiological and clinical profiles of adult CSU patients in Latvia. Materials & Methods: Patient interviews and electronic medical records from two study centres in Riga, Latvia, were reviewed. PROMs, including UCT, UAS7, USS, and CU-Q2oL, were used to assess disease control, activity, severity, and quality of life. Statistical analysis was performed using Jamovi v. 2.3.28 and IBM SPSS v. 29.0.0.0. Results: The cohort included 140 CSU patients (76.4% female; mean age 41.3 ± 14.9 years), mostly urban residents (87.1%) and non-smokers (53.6%). Urticaria with angioedema occurred in 52.1% and isolated urticaria in 47.9%, with 40% experiencing CSU for 1-5 years. Accompanying symptoms were reported by 63% and triggers by 72.9%. Allergy history and autoimmune disease diagnosis were noted in 49.3% and 29.3%. Treatment mainly involved second-generation antihistamines (85.7%) and omalizumab (17.9%). Mean scores for USS, UCT, and UAS7 were 28.8 (SD: 17.8), 8.2 (SD: 3.7), and 17.2 (SD: 14.1). UAS7 indicated severe CSU in 28.6%, and UCT suggested poorly controlled disease in 77.9%. CU-Q2oL total scores revealed mental status as the most affected domain (mean score: 51.7, SD: 28.7), with a significant association between accompanying symptoms and questionnaire scores. Conclusion: This study provides insights into the demographic and clinical aspects of CSU patients in Latvia, highlighting areas for potential improvement in patient care and emphasizing the need for further investigation into treatment outcomes and patient quality of life.

Original languageEnglish
Pages (from-to)398-408
Number of pages11
JournalEuropean Journal of Dermatology
Volume34
Issue number4
DOIs
Publication statusPublished - 1 Jul 2024

Keywords*

  • chronic spontaneous urticaria
  • clinical characteristics
  • disease control
  • quality of life

Field of Science*

  • 4.1 Agriculture, Forestry, and Fisheries
  • 4.3 Veterinary science
  • 1.6 Biological sciences
  • 3.3 Health sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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