Epidemiological, clinical, molecular features and early detection strategy of most frequent hereditary cancers in Latvia

Janis Gardovskis, Ilze Štrumfa, Edvīns Miklaševičs, Arvids Irmejs, Genadijs Trofimovičs, Egils Vjaters, Viktors Boroçenko, Inga Melbarde-Gorkuça, Andris Gardovskis, Andrejs Vanags, Andris Abele, Signe Subatniece, Marianna Bitiņa, Liana Švampane, Jekaterina Žestkova, Dace Berziņa, Karina Aksenoka, Viesturs Boka, Aldis Puķitis, Aiga StakaLaima Tihomirova

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the study was to determine epidemiological, clinical and molecular features of hereditary breast-ovarian, colorectal, endometrial, prostate and pancreatic cancer in Latvia. The study was performed from 2006 to 2009. Family cancer histories and DNA samples from 5,040 cancer cases were collected, and more than 6,000 molecular tests were performed including multiplex PCR, direct sequencing, denaturing high performance liquid chromatography and others. For the first time, a BRCA2 gene mutation positive hereditary breast cancer family was identified. The necessity of 2 BRCA1 gene founder mutations testing, irrespective of family cancer history for breast and ovarian cancer patients, was confirmed on a large number of positive cases. Regarding hereditary ovarian cancer, every ninth case affected with this malignancy was associated with the BRCA1 gene mutation. For the first time, positive familial adenomatous polyposis cases positive for APC gene mutation were reported and data on the clinical frequency of hereditary endometrial and prostate cancer were provided. In pancreatic cancer patients there was a 3.5% frequency of BRCA1 gene founder mutations.

Original languageEnglish
Pages (from-to)131-140
Number of pages10
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume63
Issue number4-5
DOIs
Publication statusPublished - 2009

Keywords

  • Breast
  • Colorectal
  • Endometrial
  • Ovarian
  • Pancreatic hereditary cancer
  • Prostate

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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