ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts

Souren Mkrtchian, Mikhail Baryshev, Ernest Sargsyan, Ioulia Chatzistamou, Aspasia Athina Volakaki, Nick Chaviaras, Agatha Pafiti, Aggeliki Triantafyllou, Hippokratis Kiaris

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Cancer cells are committed to an actively secretory state that facilitates communication with their microenvironment. We have addressed the role of ERp29, a novel endoplasmic reticulum secretion factor in mammary carcinogenesis using MCF-7 human breast cancer cells as a model. Xenografts originating from cells stably transfected with dominant-negative form of ERp29 were smaller and better differentiated than those derived from cells overexpressing wild-type ERp29. Similar effects were observed by siRNA-mediated ERp29 silencing in xenografts. However, unlike xenografts, the modulation of ERp29 in vitro did not affect the rate of cell proliferation. In addition, we have evaluated the expression of ERp29 in the resting and lactating mammary glands of mice as well as in the human primary breast tumors. About 25% of breast cancers and also lactating mammary glands were expressing ERp29 while the resting glands did not. Taken together these data suggest the active involvement of ERp29 in the malignant conversion of mammary epithelial cells.

Original languageEnglish
Pages (from-to)886-892
Number of pages7
JournalMolecular Carcinogenesis
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Keywords

  • Breast cancer
  • ERp29
  • Secretion
  • Tumor-stroma interactions

Field of Science

  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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