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Abstract
Objectives*
The aim of this study was to investigate how the revised 2024 McDonald criteria, compared to the 2017 McDonald
diagnostic criteria, particularly regarding visual diagnostics, might affect the early diagnosis, treatment, and
prognostic outcomes in patients with suspected multiple sclerosis (MS).
Materials and Methods
A retrospective cohort study was conducted using data from the Pauls Stradins University Hospital database,
including consilium decisions of MS specialists, initial magnetic resonance imaging (MRI) scans, lumbar punc-
ture results, and clinical data of patients with suspected multiple sclerosis (MS) from 2020 to 2024. Diagnostic
outcomes were compared using both the 2017 McDonald criteria and the proposed 2024 McDonald criteria.
Statistical analyses were performed using IBM SPSS Statistics (version 29 for Windows, IBM Corp., Somers, NY,
USA).
Results
Of the 79 patients evaluated for the treatment of probable multiple sclerosis, 15 did not meet the criteria for MS
according to the 2017 McDonald criteria and, consequently, were not prescribed immunomodulatory treatment
(IMT). Under the proposed 2024 McDonald criteria, 2 of these 15 patients (13%) could be diagnosed with MS and
considered for early treatment. However, this change was not statistically significant (p = 0.5).
Conclusions
Our study suggests that approximately 13% of patients could benefit from the newly revised 2024 McDonald cri-
teria, as they were not diagnosed with multiple sclerosis (MS) under the 2017 criteria. These findings highlight
that the updated criteria may facilitate earlier and more timely initiation of immunomodulatory treatment, as
well as the implementation of more aggressive treatment strategies for certain patients. While the proportion
of newly diagnosed cases remains modest, this observation underscores the robustness of the previous criteria
while demonstrating the potential for refinement to enhance early diagnostic accuracy and improve interven-
tion strategies.
The aim of this study was to investigate how the revised 2024 McDonald criteria, compared to the 2017 McDonald
diagnostic criteria, particularly regarding visual diagnostics, might affect the early diagnosis, treatment, and
prognostic outcomes in patients with suspected multiple sclerosis (MS).
Materials and Methods
A retrospective cohort study was conducted using data from the Pauls Stradins University Hospital database,
including consilium decisions of MS specialists, initial magnetic resonance imaging (MRI) scans, lumbar punc-
ture results, and clinical data of patients with suspected multiple sclerosis (MS) from 2020 to 2024. Diagnostic
outcomes were compared using both the 2017 McDonald criteria and the proposed 2024 McDonald criteria.
Statistical analyses were performed using IBM SPSS Statistics (version 29 for Windows, IBM Corp., Somers, NY,
USA).
Results
Of the 79 patients evaluated for the treatment of probable multiple sclerosis, 15 did not meet the criteria for MS
according to the 2017 McDonald criteria and, consequently, were not prescribed immunomodulatory treatment
(IMT). Under the proposed 2024 McDonald criteria, 2 of these 15 patients (13%) could be diagnosed with MS and
considered for early treatment. However, this change was not statistically significant (p = 0.5).
Conclusions
Our study suggests that approximately 13% of patients could benefit from the newly revised 2024 McDonald cri-
teria, as they were not diagnosed with multiple sclerosis (MS) under the 2017 criteria. These findings highlight
that the updated criteria may facilitate earlier and more timely initiation of immunomodulatory treatment, as
well as the implementation of more aggressive treatment strategies for certain patients. While the proportion
of newly diagnosed cases remains modest, this observation underscores the robustness of the previous criteria
while demonstrating the potential for refinement to enhance early diagnostic accuracy and improve interven-
tion strategies.
| Original language | English |
|---|---|
| Pages | 201 |
| Number of pages | 1 |
| Publication status | Published - 28 Mar 2025 |
| Event | RSU Research Week 2025: Knowledge for Use in Practice - Riga Stradiņš university, Riga, Latvia Duration: 26 Mar 2025 → 28 Mar 2025 https://rw2025.rsu.lv/conferences/knowledge-use-practice |
Conference
| Conference | RSU Research Week 2025: Knowledge for Use in Practice |
|---|---|
| Country/Territory | Latvia |
| City | Riga |
| Period | 26/03/25 → 28/03/25 |
| Other | Infections in the Development of Non-Communicable Diseases |
| Internet address |
Keywords*
- Multiple Sclerosis
- MRI
- Retrospective Study
- 2024 McDonald criteria
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
Fingerprint
Dive into the research topics of 'Evaluating Changes in Initial Diagnosis and Treatment of Multiple Sclerosis with Updated Diagnostic Criteria: Retrospective Study'. Together they form a unique fingerprint.Research output
- 1 Book
-
Rīga Stradiņš University International Research Conference on Medical and Health Care Sciences “Knowledge for Use in Practice”: Abstracts, 26-28 March, 2025
Rīga Stradiņš University, 2025, Rīga: Rīga Stradiņš University. 478 p.Research output: Book/Report › Book › peer-review
Open Access