Evaluation of physicochemical properties of amphiphilic 1,4-dihydropyridines and preparation of magnetoliposomes

Oksana Petrichenko (Coresponding Author), Aiva Plotniece, Karlis Pajuste, Martins Rucins, Pavels Dimitrijevs, Arkadij Sobolev, Einars Sprugis, Andrejs Cēbers

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This study was focused on the estimation of the targeted modification of 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties of 1,4-DHP (C12, C14 and C16 ); (2) N-substituent at position 1 of 1,4-DHP (N-H or N-CH3 ); (3) substituents of pyridinium moieties at positions 2 and 6 of 1,4-DHP (H, 4-CN and 3-Ph); (4) substituent at position 4 of 1,4-DHP (phenyl and napthyl) on physicochemical properties of the entire molecules and on the characteristics of the obtained magnetoliposomes formed by them. It was shown that thermal behavior of the tested 1,4-DHP amphiphiles was related to the alkyl chains length, the elongation of which decreased their transition temperatures. The properties of 1,4-DHP amphiphile monolayers and their polar head areas were determined. The packing parameters of amphiphiles were in the 0.43–0.55 range. It was demonstrated that the structure of 1,4-DHPs affected the physicochemical properties of compounds. “Empty” liposomes and magnetoliposomes were prepared from selected 1,4-DHP amphiphiles. It was shown that the variation of alkyl chains length or the change of substituents at positions 4 of 1,4-DHP did not show a significant influence on properties of liposomes.

Original languageEnglish
Article number593
Number of pages17
JournalNanomaterials
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords*

  • 1,4-dihydropyridine amphiphiles
  • Iron oxide nanoparticles
  • Lipid monolayers
  • Magnetoliposomes
  • Physicochemical properties

Field of Science*

  • 1.4 Chemical sciences
  • 2.4 Chemical engineering
  • 2.5 Materials engineering

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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