Evaluation of Signs of Skin Aging in Patients with Metabolic Syndrome after Substitution Therapy with Antioxidants: Summary of the Doctoral Thesis

Research output: Types of ThesisDoctoral Thesis


Skin aging is a complex biological phenomenon consisting of two overlapping components: internal (true aging) and external. OS, which is believed to play a central pathogenic role in the development of MetS, is a state of prooxidant / antioxidant imbalance in which the net amount of Reactive Oxygen Species (ROS) exceeds the body's antioxidant defenses. Excess ROS can cause lipid, protein oxidation, and oxidative damage to DNA. MetS is a syndrome, of which main symptoms are obesity, insulin resistance (IR), dyslipidemia and hypertension or high blood pressure. About a third of the adult population in developing countries is currently classified as having MetS according to various criteria (Moore and Chaudhary, and Akinyemiju, 2017). The use of AO has been observed to reduce the OS and inflammatory response involved in the development of MetS (Soory, 2012). The effects of selenium on the expression and secretion of inflammatory and OS biomarkers have been studied in vitro and in vivo in experimental MetS models as well as in humans. There are many studies in the literature on various parameters influenced by blood selenium (Se) levels, such as C-reactive protein, interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and retinol-binding protein (Rayman, 2000; Alissa and Bahijri, and Ferns, 2003). Intake of Se and other AOs is associated with lower C-reactive protein (CRP) in women, indicating a possible anti-inflammatory effect of dietary AO. The above is also relevant in Latvia but has not been studied. There are patients with diabetes, light skin phototype, MetS, cardiovascular diseases in Latvia, but visual changes do not give a complete picture of the aging processes in the skin. Aim of the study. To study the signs of skin photoaging and evaluate the effectiveness of AO therapy in patients with MetS in the Latvian population. Tasks of the study: 1. Evaluate MetS symptoms and skin parameters in MetS patients and control groups. 2. Identify and describe the signs of skin aging in the group of MetS patients (visually, as well as using dermatoscopic and histological examination). 3. Evaluate the skin changes after organic selenium substitution. 4. Evaluate the interrelationships between MetS symptoms, OS parameters and skin changes in MetS patients and control groups. Hypothesis: AO substitution improves skin aging parameters in MetS patients.
Original languageEnglish
  • Ķīsis, Jānis, First/Primary/Lead supervisor
  • Voicehovska, Jūlija, Second/Co-supervisor
  • Kleina, Regīna, Consultant/Advisor
Place of PublicationRīga
Publication statusPublished - 1 Jan 2021


  • Sector – Clinical Medicine
  • Subsection – Internal Medicine
  • metabolic syndrome
  • oxidative stress
  • skin ageing
  • free radicals
  • Summary of the Doctoral Thesis

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 4. Doctoral Thesis


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