Projects per year
Abstract
Methods: Blood plasma samples from 10 HAE (types 1/2) patients, 15 patients with idiopathic AE, and 20 healthy controls were collected in Latvia and analyzed using LC-MS based targeted metabolomics workflow. T-test and fold change calculation were used to identify metabolites with significant differences between diseases and control groups. ROC analysis was performed to evaluate metabolite based classification model.
Results: A total of 33 metabolites were detected and quantified. The results showed that isovalerylcarnitine, cystine, and hydroxyproline were the most significantly altered metabolites between the disease and control groups. Aspartic acid was identified as a significant metabolite that could differentiate between HAE and idiopathic AE. The mathematical combination of metabolites (hydroxyproline * cystine)/(creatinine * isovalerylcarnitine) was identified as the diagnosis signature for HAE. Furthermore, glycine/asparagine ratio could differentiate between HAE and idiopathic AE.
Conclusion: Our study identified isovalerylcarnitine, cystine, and hydroxyproline as potential biomarkers for HAE diagnosis. Identifying new biomarkers may offer enhanced prospects for accurate, timely, and economical diagnosis of HAE, as well as tailored treatment selection for optimal patient care.
Original language | English |
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Article number | 1324671 |
Journal | Frontiers in Immunology |
Volume | 25 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2024 |
Keywords*
- C1 inhibitor
- biomarkers
- diagnosis
- Hereditary angioedema
- Metabolome
Field of Science*
- 3.1 Basic medicine
- 3.3 Health sciences
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
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Doctoral grant for RSU and LASE PhD students
Edelmers, E. (Expert (PhD student)), Gavrilova, A. (Expert (PhD student)), Lucāne, Z. (Expert (PhD student)), Elksne, E. (Expert (PhD student)), Lazovska, M. (Expert (PhD student)), Miķelsone, M. (Expert (PhD student)), Griķe, I. (Expert (PhD student)), Antonovičs, K. (Expert (PhD student)), Šetlere, S. (Expert (PhD student)), Kivrāne, A. (Expert (PhD student)), Semenistaja, S. (Expert (PhD student)), Ļubina, O. (Expert (PhD student)), Ivanova, K. (Expert (PhD student)), Kaņepa, A. (Expert (PhD student)), Glāzere, I. (Expert (PhD student)), Nikolajeva, K. (Expert (PhD student)), Saliņa, A. (Expert (PhD student)), Rozevska, M. (Expert (PhD student)), Ničiporuka, R. (Expert (PhD student)), Mičko, L. (Expert (PhD student)), Ruža, I. (Expert (PhD student)), Lapiņa, L. (Expert (PhD student)), Šetlers, K. (Expert (PhD student)), Rubene, L. (Expert (PhD student)), Lejnieks, M. (Expert (PhD student)), Līkopa, Z. (Expert (PhD student)), Kozlovs, N. (Expert (PhD student)), Reine, A. (Expert (PhD student)), Palkova, A. (Expert (PhD student)), Karulis, M. (Expert (PhD student)), Kuļigina, N. (Expert (PhD student)), Kalniņa, D. (Expert (PhD student)), Svempe, L. (Expert (PhD student)), Saukuma, I. (Expert (PhD student)), Juberte-Krūmiņa, L. (Expert (PhD student)), Kovaļovs, A. (Expert (PhD student)), Sinulingga, A. R. (Expert (PhD student)), Iļjins, A. (Expert (PhD student)), Laviņš, R. (Expert (PhD student)), Šteinmane, V. (Expert (PhD student)), Spundiņa, L. (Expert (PhD student)), Bleidelis, I. (Expert (PhD student)), Martinsone, S. S. (Expert (PhD student)), Teteris, L. E. (Expert (PhD student)), Jakovics, M. (Expert (PhD student)) & Nerets, R. (Expert (PhD student))
2/09/24 → 31/05/26
Project: Consolidation grants
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BBCE: Baltic Biomaterials Centre of Excellence, Phase II
Ločs, J. (Project leader), Bandere, D. (Leading expert), Logviss, K. (Work package leader), Brangule, A. (Partner's coordinator), Krūmiņa, J. (Work package leader), Bārzdiņa, A. (Expert (PhD student)) & Prudņikova, D. P. (Assistant (student))
1/01/20 → 31/12/26
Project: EU Programmes › Horizon 2020
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Predominantly primary antibody deficiencies among adults: solving etiology and causes of clinical variability
Kurjāne, N. (Project leader), Gailīte, L. (Leading expert), Rots, D. (Participant), Kaņepa, A. (Assistant (student)), Lucāne, Z. (Assistant (student)), Nartiša, I. (Assistant (student)), Neiburga, K. D. (Assistant (student)), Ozola, L. (Participant) & Ķēniņa, V. (Expert)
1/01/21 → 31/12/23
Project: Fundamental and Applied Research Programme