Expression of galanin and the GALR1 galanin receptor subtype in the colon of children with paradoxical fecal incontinence

Arnis Engelis, Dzintars Mozgis, K. A. Pine, J. Shine, T. P. Lismaa, M. Pilmane

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Galanin is a 29-30 amino acid peptide originally isolated from porcine upper small intestine and subsequently from a number of vertebrate species.1 Galanin is expressed in the neurons and nerve fibers of the gastrointestinal tract of mammals,2,3 and regulates
ion absorption in ileal tissue4 and the contractile activity of digestive smooth muscle.5–7 Three galanin receptor subtypes have been cloned to date.1 The GALR1 subtype is expressed in the normal human gastrointestinal tract,8 but its expression in diseased gastrointestinal tissue is not known. In this study, we examined the distribution of galaninergic fibers and expression of GALR1 in mucosal epithelial cells in the colon of children with evacuation disorders of the bowel.
Original languageEnglish
Title of host publicationGalanin
Subtitle of host publicationbasic research discoveries and therapeutic implications
EditorsT. Hokfelt, T. Bartfai, J. Crawley
Place of PublicationNew York
PublisherNew York Academy of Sciences
Pages425-429
Number of pages5
Volume863
DOIs
Publication statusPublished - 1998
EventConference on Galanin - Basic Research Discoveries and Therapeutic Implications - Stockholm, Sweden
Duration: 3 May 19985 May 1998

Publication series

NameAnnals of the New York Academy of Sciences
PublisherWiley-Blackwell
ISSN (Print)0077-8923

Conference

ConferenceConference on Galanin - Basic Research Discoveries and Therapeutic Implications
Country/TerritorySweden
CityStockholm
Period3/05/985/05/98

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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