Projects per year
Abstract
Chemokines and their receptors regulate migration and infiltration of immune cells. CCR1 and CCR2 respond to the same chemokines, which are secreted abundantly upon inflammation and in lymphoid organs also.
Chronic lymphocytic leukemia (CLL) is the most common type of hematological malignancies in adults. CLL demonstrates highly variable courses of the disease. The clinical staging systems define three major groups of patients with distinct clinical outcome: low-risk, intermediate, and high-risk disease. While patients with the low-risk (indolent) disease do not need the chemoimmunotherapies, patients with the high-risk CLL require therapy immediately after the diagnosis. The high-risk rapidly progressing CLL is characterized by involvement of the secondary lymphoid organs. Expression of CD38 on CLL cells has been associated with poor clinical outcomes in patients.
In our study of 90 untreated CLL patients, we analyzed the cell-surface expression of the chemokine receptors CCR1 and CCR2, along with CD38, on the peripheral blood (PB) CD19+CD5+ lymphocytes, using the multi-parameter flow cytometry (mFC) assay. The frequency of the CCR1/CCR2-expressing CD19+CD5+ cells positively correlated with the frequency of the CD38-expressing lymphocytes.
Detection of CCR1 and CCR2 on circulating leukemic cells could be suggested, in addition to CD38, for the clinical FC analyses, to assure accurate prognoses of the high-risk progression in CLL.
This research was supported by the Latvian Council of Science project No. lzp-2018/1-0156.
Chronic lymphocytic leukemia (CLL) is the most common type of hematological malignancies in adults. CLL demonstrates highly variable courses of the disease. The clinical staging systems define three major groups of patients with distinct clinical outcome: low-risk, intermediate, and high-risk disease. While patients with the low-risk (indolent) disease do not need the chemoimmunotherapies, patients with the high-risk CLL require therapy immediately after the diagnosis. The high-risk rapidly progressing CLL is characterized by involvement of the secondary lymphoid organs. Expression of CD38 on CLL cells has been associated with poor clinical outcomes in patients.
In our study of 90 untreated CLL patients, we analyzed the cell-surface expression of the chemokine receptors CCR1 and CCR2, along with CD38, on the peripheral blood (PB) CD19+CD5+ lymphocytes, using the multi-parameter flow cytometry (mFC) assay. The frequency of the CCR1/CCR2-expressing CD19+CD5+ cells positively correlated with the frequency of the CD38-expressing lymphocytes.
Detection of CCR1 and CCR2 on circulating leukemic cells could be suggested, in addition to CD38, for the clinical FC analyses, to assure accurate prognoses of the high-risk progression in CLL.
This research was supported by the Latvian Council of Science project No. lzp-2018/1-0156.
Original language | English |
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Pages | P-32 |
Number of pages | 1 |
Publication status | Published - 13 Dec 2021 |
Event | 2nd International Conference "Cancer Metastasis" - virtual, Austria Duration: 13 Dec 2021 → 17 Dec 2021 Conference number: 2 https://www.mts-conf.at/ |
Conference
Conference | 2nd International Conference "Cancer Metastasis" |
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Country/Territory | Austria |
Period | 13/12/21 → 17/12/21 |
Internet address |
Keywords*
- CLL, high-risk progression, CD38, CCR1, CCR2
Field of Science*
- 1.6 Biological sciences
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
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- 1 Finished
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Investigation of the chemokine receptors CCR1 and CCR2 and EBV infection aimed on disclosure of new markers that can predict the high risk for progression of chronic lymphocytic leukemia
Holodņuka, I. (Project leader), Kozireva, S. (Participant), Zvejniece, L. (Expert (PhD student)), Pavlova, J. (Participant) & Demida, O. (Assistant (student))
31/08/18 → 30/11/21
Project: Fundamental and Applied Research Programme