Expression of the chemokine receptors CCR1 and CCR2 on the circulating leukemic cells of patients with the high-risk chronic lymphocytic leukemia.

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Chemokines and their receptors regulate migration and infiltration of immune cells. CCR1 and CCR2 respond to the same chemokines, which are secreted abundantly upon inflammation and in lymphoid organs also.
Chronic lymphocytic leukemia (CLL) is the most common type of hematological malignancies in adults. CLL demonstrates highly variable courses of the disease. The clinical staging systems define three major groups of patients with distinct clinical outcome: low-risk, intermediate, and high-risk disease. While patients with the low-risk (indolent) disease do not need the chemoimmunotherapies, patients with the high-risk CLL require therapy immediately after the diagnosis. The high-risk rapidly progressing CLL is characterized by involvement of the secondary lymphoid organs. Expression of CD38 on CLL cells has been associated with poor clinical outcomes in patients.
In our study of 90 untreated CLL patients, we analyzed the cell-surface expression of the chemokine receptors CCR1 and CCR2, along with CD38, on the peripheral blood (PB) CD19+CD5+ lymphocytes, using the multi-parameter flow cytometry (mFC) assay. The frequency of the CCR1/CCR2-expressing CD19+CD5+ cells positively correlated with the frequency of the CD38-expressing lymphocytes.
Detection of CCR1 and CCR2 on circulating leukemic cells could be suggested, in addition to CD38, for the clinical FC analyses, to assure accurate prognoses of the high-risk progression in CLL.
This research was supported by the Latvian Council of Science project No. lzp-2018/1-0156.
Original languageEnglish
Number of pages1
Publication statusPublished - 13 Dec 2021
Event2nd International Conference "Cancer Metastasis" - virtual, Austria
Duration: 13 Dec 202117 Dec 2021
Conference number: 2


Conference2nd International Conference "Cancer Metastasis"
Internet address


  • CLL, high-risk progression, CD38, CCR1, CCR2

Field of Science*

  • 1.6 Biological sciences
  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


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