External respiration function and quality of life in patients with bronchial asthma in correction of selenium deficiency

J. G. Voicehovska; G. A. Orlikov; Yu G. Karpov; U. Teibe; A. D. Ivanov; I. Baidekalne; N. V. Voicehovskis; E. Maulins

External respiration function and quality of life in patients with bronchial asthma in correction of selenium deficiency

J. G. Voicehovska, G. A. Orlikov, Yu G. Karpov, U. Teibe, A. D. Ivanov, I. Baidekalne, N. V. Voicehovskis, E. Maulins

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Aim. To examine the effect of selenium (Se) adjuvant therapy on external respiration function (ERF) and quality of life (QOL) in bronchial asthma (BA) patients. Material and methods. 26 patients with BA received standard therapy and adjuvant 200 mcg/day selenium (SelenoPRECISE, PharmaNord, Denmark) for 16 weeks. ERF was estimated by FEV1 and FVC, QOF - by the response to Juniper Adult Asthma Quality of life Short Questionnaire (AQLQ-S) at initiation and end of the study Difference with the baseline was assessed using Paired Samples T-Test, SPSS 14.0. Results. Paired-samples T-test showed that FVC increased significantly from 76.5 ± 23.8% to 81.8 ± 23.2% (p = 0.015). FEV1 showed a significant increase from 62.3 ± 29.6% to 67.7 ± 28.1% (p = 0.018). Total AQLQ score elevated from 3.25 to 4.71 (p = 0.01). Conclusion. Correction of Se deficiency in BA patients on standard therapy improves ERF and BA-related QOL. Mechanisms of a protective Se action are involved in antioxidant defense by means of Se participation in enzymatic detoxication of peroxides and a stabilizing effect on biomembranes.

Original language	English
Pages (from-to)	38-41
Number of pages	4
Journal	Terapevticheskii Arkhiv
Volume	79
Issue number	8
Publication status	Published - 2007
Externally published	Yes

Keywords*

Antioxidants
Bronchial asthma
Selenium

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{aef2fe0c8d114f8b877e3103817bb824,

title = "External respiration function and quality of life in patients with bronchial asthma in correction of selenium deficiency",

abstract = "Aim. To examine the effect of selenium (Se) adjuvant therapy on external respiration function (ERF) and quality of life (QOL) in bronchial asthma (BA) patients. Material and methods. 26 patients with BA received standard therapy and adjuvant 200 mcg/day selenium (SelenoPRECISE, PharmaNord, Denmark) for 16 weeks. ERF was estimated by FEV1 and FVC, QOF - by the response to Juniper Adult Asthma Quality of life Short Questionnaire (AQLQ-S) at initiation and end of the study Difference with the baseline was assessed using Paired Samples T-Test, SPSS 14.0. Results. Paired-samples T-test showed that FVC increased significantly from 76.5 ± 23.8% to 81.8 ± 23.2% (p = 0.015). FEV1 showed a significant increase from 62.3 ± 29.6% to 67.7 ± 28.1% (p = 0.018). Total AQLQ score elevated from 3.25 to 4.71 (p = 0.01). Conclusion. Correction of Se deficiency in BA patients on standard therapy improves ERF and BA-related QOL. Mechanisms of a protective Se action are involved in antioxidant defense by means of Se participation in enzymatic detoxication of peroxides and a stabilizing effect on biomembranes.",

keywords = "Antioxidants, Bronchial asthma, Selenium",

author = "Voicehovska, {J. G.} and Orlikov, {G. A.} and Karpov, {Yu G.} and U. Teibe and Ivanov, {A. D.} and I. Baidekalne and Voicehovskis, {N. V.} and E. Maulins",

year = "2007",

language = "English",

volume = "79",

pages = "38--41",

journal = "Terapevticheskii Arkhiv",

issn = "0040-3660",

publisher = "Consilium MediCum",

number = "8",

}

TY - JOUR

T1 - External respiration function and quality of life in patients with bronchial asthma in correction of selenium deficiency

AU - Voicehovska, J. G.

AU - Orlikov, G. A.

AU - Karpov, Yu G.

AU - Teibe, U.

AU - Ivanov, A. D.

AU - Baidekalne, I.

AU - Voicehovskis, N. V.

AU - Maulins, E.

PY - 2007

Y1 - 2007

N2 - Aim. To examine the effect of selenium (Se) adjuvant therapy on external respiration function (ERF) and quality of life (QOL) in bronchial asthma (BA) patients. Material and methods. 26 patients with BA received standard therapy and adjuvant 200 mcg/day selenium (SelenoPRECISE, PharmaNord, Denmark) for 16 weeks. ERF was estimated by FEV1 and FVC, QOF - by the response to Juniper Adult Asthma Quality of life Short Questionnaire (AQLQ-S) at initiation and end of the study Difference with the baseline was assessed using Paired Samples T-Test, SPSS 14.0. Results. Paired-samples T-test showed that FVC increased significantly from 76.5 ± 23.8% to 81.8 ± 23.2% (p = 0.015). FEV1 showed a significant increase from 62.3 ± 29.6% to 67.7 ± 28.1% (p = 0.018). Total AQLQ score elevated from 3.25 to 4.71 (p = 0.01). Conclusion. Correction of Se deficiency in BA patients on standard therapy improves ERF and BA-related QOL. Mechanisms of a protective Se action are involved in antioxidant defense by means of Se participation in enzymatic detoxication of peroxides and a stabilizing effect on biomembranes.

AB - Aim. To examine the effect of selenium (Se) adjuvant therapy on external respiration function (ERF) and quality of life (QOL) in bronchial asthma (BA) patients. Material and methods. 26 patients with BA received standard therapy and adjuvant 200 mcg/day selenium (SelenoPRECISE, PharmaNord, Denmark) for 16 weeks. ERF was estimated by FEV1 and FVC, QOF - by the response to Juniper Adult Asthma Quality of life Short Questionnaire (AQLQ-S) at initiation and end of the study Difference with the baseline was assessed using Paired Samples T-Test, SPSS 14.0. Results. Paired-samples T-test showed that FVC increased significantly from 76.5 ± 23.8% to 81.8 ± 23.2% (p = 0.015). FEV1 showed a significant increase from 62.3 ± 29.6% to 67.7 ± 28.1% (p = 0.018). Total AQLQ score elevated from 3.25 to 4.71 (p = 0.01). Conclusion. Correction of Se deficiency in BA patients on standard therapy improves ERF and BA-related QOL. Mechanisms of a protective Se action are involved in antioxidant defense by means of Se participation in enzymatic detoxication of peroxides and a stabilizing effect on biomembranes.

KW - Antioxidants

KW - Bronchial asthma

KW - Selenium

UR - http://www.scopus.com/inward/record.url?scp=35148833848&partnerID=8YFLogxK

M3 - Article

C2 - 17926469

AN - SCOPUS:35148833848

SN - 0040-3660

VL - 79

SP - 38

EP - 41

JO - Terapevticheskii Arkhiv

JF - Terapevticheskii Arkhiv

IS - 8

ER -

External respiration function and quality of life in patients with bronchial asthma in correction of selenium deficiency

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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