EXTRACTION OF B12 REFERENCE INTERVALS FROM A LARGE AMOUNT OF GENERAL PATIENT DATA

Didzis Gavars, Dmitry Perminov, Eriks Tauckels, Ilze Lindenberga, Anna Tutāne, Agris Auce (Corresponding Author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This study compared the reference intervals (RI) of B12 vitamin concentration in blood found in the literature with RIs extracted from data accumulated from a large number of patients by E. Gulbis Laboratory in Latvia. This paper investigated and demonstrated the possibility of using large amounts of random patient data to establish the RI for clinical laboratory tests. The blood level of B12 vitamin was selected as the model system for this study. The study used blind data for B12 blood level measurements from 132 379 patients accumulated in E. Gulbis Laboratory over a period of 15 years. In order to establish the reference intervals, the frequency distribution of log transformed B12 values was fit to a Gaussian distribution. The established B12 reference interval of 196 pg/ml and 942 pg/ml was found to be in good agreement with RIs reported elsewhere.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume76
Issue number3
DOIs
Publication statusPublished - Jun 2022
Externally publishedYes

Keywords*

  • B12 local reference interval
  • B12 vitamin
  • clinical analysis
  • large patient data
  • method of calculating reference interval

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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