TY - JOUR
T1 - Extreme duration exercise affects old and younger men differently
AU - Frandsen, Jacob
AU - Sahl, Ronni Eg
AU - Rømer, Tue
AU - Hansen, Mikkel Thunestvedt
AU - Nielsen, Andreas Blaaholm
AU - Lie-Olesen, Michelle Munk
AU - Rasmusen, Hanne Kruuse
AU - Søgaard, Ditte
AU - Ingersen, Arthur
AU - Rosenkilde, Mads
AU - Westerterp, Klaas
AU - Holst, Jens Juul
AU - Andersen, Jesper Løvind
AU - Markowski, Adam Roman
AU - Blachnio-Zabielska, Agnieszka
AU - Clemmensen, Christoffer
AU - Sacchetti, Massimo
AU - Cataldo, Angelo
AU - Traina, Marcello
AU - Larsen, Steen
AU - Dela, Flemming
AU - Helge, Jørn Wulff
N1 - Publisher Copyright:
© 2022 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.
PY - 2022/7
Y1 - 2022/7
N2 - Aim & Methods: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30 ± 5 years or age 65 ± 6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days. Results: Over the 15-day exercise intervention, participants lost 2–3 kg fat mass with no significant change in body weight. V̇O2max did not change in younger cyclists, but decreased (p = 0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased in the younger group. In the older cohort, plasma LDL-cholesterol and plasma triglyceride decreased. In skeletal muscle, fat transporters CD36 and FABPm remained unchanged. The glucose handling proteins GLUT4 and SNAP23 increased in both groups. Mitochondrial ROS production decreased in both groups, and ADP sensitivity increased in skeletal muscle in the older but not in the younger cohort. Conclusion: In summary, these data suggest that older but not younger individuals experience a negative adaptive response affecting cardiovascular function in response to extreme endurance exercise, while a positive response to the same exercise intervention is observed in peripheral tissues in younger and older men. The results also suggest that the adaptive thresholds differ in younger and old men, and this difference primarily affects central cardiovascular functions in older men after extreme endurance exercise.
AB - Aim & Methods: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30 ± 5 years or age 65 ± 6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days. Results: Over the 15-day exercise intervention, participants lost 2–3 kg fat mass with no significant change in body weight. V̇O2max did not change in younger cyclists, but decreased (p = 0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased in the younger group. In the older cohort, plasma LDL-cholesterol and plasma triglyceride decreased. In skeletal muscle, fat transporters CD36 and FABPm remained unchanged. The glucose handling proteins GLUT4 and SNAP23 increased in both groups. Mitochondrial ROS production decreased in both groups, and ADP sensitivity increased in skeletal muscle in the older but not in the younger cohort. Conclusion: In summary, these data suggest that older but not younger individuals experience a negative adaptive response affecting cardiovascular function in response to extreme endurance exercise, while a positive response to the same exercise intervention is observed in peripheral tissues in younger and older men. The results also suggest that the adaptive thresholds differ in younger and old men, and this difference primarily affects central cardiovascular functions in older men after extreme endurance exercise.
KW - aerobic fitness
KW - aging
KW - cycling
KW - endurance exercise
KW - energy metabolism
KW - fat oxidation
KW - muscle biopsy
UR - http://www.scopus.com/inward/record.url?scp=85128271666&partnerID=8YFLogxK
U2 - 10.1111/apha.13816
DO - 10.1111/apha.13816
M3 - Article
C2 - 35347845
AN - SCOPUS:85128271666
SN - 1748-1708
VL - 235
JO - Acta Physiologica
JF - Acta Physiologica
IS - 3
M1 - e13816
ER -