F11 gene polymorphism in patients with vein thrombosis in the population of Latvia

Irina Kajuna (Coresponding Author), Helena Mikažane, Valda Stanevica

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Deep vein thrombosis (DVT) is the result of innate thrombotic tendency and nongenetic triggers. Recent studies have found an association between DVT and single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that contains the gene encoding factor XI (F11), a cytochrome P450 family member (CYP4V2). METHODS: The study group consisted of 99 DVT patients. The control group consisted of 99 individuals. We investigated the association of 8 SNPs genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) with DVT patients in Latvia. RESULTS: We found that polymorphism of the F11 gene (rs2289252) was associated with an increased risk of DVT (OR=2.19, P=0.0004). CONCLUSIONS: The F11 gene (rs2289252) polymorphism showed an association with VT in the Latvian population.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalActa Phlebologica
Issue number3
Publication statusPublished - Dec 2018


  • Deep venous thrombosis
  • Single nucleotide polymorphisms
  • Thrombosis

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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