F11 gene polymorphism in patients with vein thrombosis in the population of Latvia

Irina Kajuna; Helena Mikažane; Valda Stanevica

doi:10.23736/S1593-232X.18.00419-8

F11 gene polymorphism in patients with vein thrombosis in the population of Latvia

Irina Kajuna (Corresponding Author), Helena Mikažane, Valda Stanevica

Rīga Stradiņš University

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Deep vein thrombosis (DVT) is the result of innate thrombotic tendency and nongenetic triggers. Recent studies have found an association between DVT and single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that contains the gene encoding factor XI (F11), a cytochrome P450 family member (CYP4V2). METHODS: The study group consisted of 99 DVT patients. The control group consisted of 99 individuals. We investigated the association of 8 SNPs genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) with DVT patients in Latvia. RESULTS: We found that polymorphism of the F11 gene (rs2289252) was associated with an increased risk of DVT (OR=2.19, P=0.0004). CONCLUSIONS: The F11 gene (rs2289252) polymorphism showed an association with VT in the Latvian population.

Original language	English
Pages (from-to)	87-90
Number of pages	4
Journal	Acta Phlebologica
Volume	19
Issue number	3
DOIs	https://doi.org/10.23736/S1593-232X.18.00419-8
Publication status	Published - Dec 2018

Keywords*

Deep venous thrombosis
Single nucleotide polymorphisms
Thrombosis

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.23736/S1593-232X.18.00419-8

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@article{83582784567643b8a58cae728f3ade26,

title = "F11 gene polymorphism in patients with vein thrombosis in the population of Latvia",

abstract = "BACKGROUND: Deep vein thrombosis (DVT) is the result of innate thrombotic tendency and nongenetic triggers. Recent studies have found an association between DVT and single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that contains the gene encoding factor XI (F11), a cytochrome P450 family member (CYP4V2). METHODS: The study group consisted of 99 DVT patients. The control group consisted of 99 individuals. We investigated the association of 8 SNPs genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) with DVT patients in Latvia. RESULTS: We found that polymorphism of the F11 gene (rs2289252) was associated with an increased risk of DVT (OR=2.19, P=0.0004). CONCLUSIONS: The F11 gene (rs2289252) polymorphism showed an association with VT in the Latvian population.",

keywords = "Deep venous thrombosis, Single nucleotide polymorphisms, Thrombosis",

author = "Irina Kajuna and Helena Mika{\v z}ane and Valda Stanevica",

note = "Publisher Copyright: {\textcopyright} 2018 EDIZIONI MINERVA MEDICA.",

year = "2018",

month = dec,

doi = "10.23736/S1593-232X.18.00419-8",

language = "English",

volume = "19",

pages = "87--90",

journal = "Acta Phlebologica",

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TY - JOUR

T1 - F11 gene polymorphism in patients with vein thrombosis in the population of Latvia

AU - Kajuna, Irina

AU - Mikažane, Helena

AU - Stanevica, Valda

PY - 2018/12

Y1 - 2018/12

N2 - BACKGROUND: Deep vein thrombosis (DVT) is the result of innate thrombotic tendency and nongenetic triggers. Recent studies have found an association between DVT and single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that contains the gene encoding factor XI (F11), a cytochrome P450 family member (CYP4V2). METHODS: The study group consisted of 99 DVT patients. The control group consisted of 99 individuals. We investigated the association of 8 SNPs genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) with DVT patients in Latvia. RESULTS: We found that polymorphism of the F11 gene (rs2289252) was associated with an increased risk of DVT (OR=2.19, P=0.0004). CONCLUSIONS: The F11 gene (rs2289252) polymorphism showed an association with VT in the Latvian population.

AB - BACKGROUND: Deep vein thrombosis (DVT) is the result of innate thrombotic tendency and nongenetic triggers. Recent studies have found an association between DVT and single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that contains the gene encoding factor XI (F11), a cytochrome P450 family member (CYP4V2). METHODS: The study group consisted of 99 DVT patients. The control group consisted of 99 individuals. We investigated the association of 8 SNPs genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) with DVT patients in Latvia. RESULTS: We found that polymorphism of the F11 gene (rs2289252) was associated with an increased risk of DVT (OR=2.19, P=0.0004). CONCLUSIONS: The F11 gene (rs2289252) polymorphism showed an association with VT in the Latvian population.

KW - Deep venous thrombosis

KW - Single nucleotide polymorphisms

KW - Thrombosis

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U2 - 10.23736/S1593-232X.18.00419-8

DO - 10.23736/S1593-232X.18.00419-8

M3 - Article

AN - SCOPUS:85059761544

SN - 1593-232X

VL - 19

SP - 87

EP - 90

JO - Acta Phlebologica

JF - Acta Phlebologica

IS - 3

ER -

F11 gene polymorphism in patients with vein thrombosis in the population of Latvia

Abstract

Keywords*

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