Factors of angiogenesis and regeneration of epidermic tissues

Allergic affection of the skin and respiratory tracts emplies the same mechanism of development: eosinophilia, increased production of immunoglobulin E (IgE), release of histamine, the presence of IgH-antibodies. Provocation of eosinophilia and IgH-reaction is activated by different antigens. According to immunopharmacological conception, blood monocytes play an essential role in skin affection as they are main antigen-presenting cells. The latter are responsible for contact sensitization. i.e. for induction of contact sensitivity in interaction of T-lymphocytes with antigen-presenting cells. Lymphocytes response to the antigen consists in digestion, metabolic transformation and presentation of the antigen on cell surface. Activated circulating T-lymphocytes reach the place of the antigen action. Interaction of the antigen with T-cells enhances their proliferation and secretion of interleukines (cytokines produced by leukocytes). Cascade development of inflammation mediators is observed. Development of allergic inflammation includes active migration of cells dependent on functional activity of ICAM-3 adhesion molecule. To weaken allergens action, it is suggested to use mechanisms inhibiting action of the molecule ICAM-3 and thus inhibiting migration of cells. Capillary endothelium and microvascular net "direct" the process of inflammation and the response to it. Endothelial cells link circulating macrophages, monocytes, neutrophils, cytokines and other inflammation mediators with organ cells. Cells of capillary endothelium stimulated by cytokines guide leukocytes to the site of damage. Neutrophilic leukocytes stimulate synthesis of collagenase which can destruct basal membrane of the endothelium. Process of angiogenesis comprises mobilization of capillary endothelium and its proliferation after destruction of the basal membrane. Reparative regeneration of damaged epithelial tissues depends on new growth of capillaries, proliferation of capillary endothelium. Processes of angiogenesis, proliferation of capillary endothelium and reparative regeneration of the affected epidermic tissues are related to angiogenesis factor (growth factors) presence in the tissues. Specific action of growth factors and collagenase do not manifest in the absence of tissue copper ions.