Fluid and vasopressor therapy in Intensive Care Unit patients with community acquired pneumonia induced septic shock

The aim of this study was to estimate effect of infusion and vasopressor therapy on a mortality of Intensive Care Unit (ICU) patients admitted with community acquired pneumonia (CAP) induced septic shock. A data of 25 patients with a CAP induced septic shock admitted to the ICU of Pauls Stradins Clinical University hospital at 2019 was retrospectively analysed. Dynamic of the administered fluid volumes, vasopressor doses, clinical and laboratory variables within the first 3 days from admission were compared between survivors and non-survivors. For statistical analysis IBM SPSS Statistics 26.0 was used. Surviving group included 10, non-surviving group included 11 patients. Data of 4 patients who passed away in the first 24 hours from admission were excluded from analysis. Surviving patient group were statistically significantly younger than non-surviving group. Administered fluid volumes were similar in both groups. Surviving patients received lower vasopressor median doses and vasopressor support was declined within study period. Initial lactate levels were lower in the surviving group and in dynamic decreased more than in the non-surviving group. Age, initial lactate level and lactate dynamic is important predictors for the outcome in the ICU patients with CAP induced septic shock. Required vasopressor doses and magnitude of the dose dynamic are associated with ICU mortality. Administered fluid volume does not contribute significantly to ICU mortality.