Forecast of numerical optimization progress of biochemical networks

Ivars Mozga (Corresponding Author), Andrejs Kostromins, Egils Stalidzans

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Citations (Scopus)

Abstract

Increasing size of biochemical models of cellular processes influence the time consumption for optimization of control systems in biotechnological plants to increase the productivity. Nonlinear systems of differential equations can be optimized by time consuming stochastic numerical methods that work for most different nonlinear models but can not guarantee finding of the global optimum. In case of a high number of possible parameter combinations early rejection of parameter combinations with low potential of criteria increase becomes important. Statistics of convergence dynamics is collected to predict the optimization potential of optimization parameter combinations and use them for early rejection of parameter combinations with low optimization potential. A prediction tool is developed to predict the distance to the global optimum depending on the number of parameters, size of the model, and the number of parameters in the model. The prediction tool returns distance to the expected optimal solution as a function of Central Processor Unit (CPU) time. The forecast tool can be used for models of different size and using different numerical optimization methods.

Original languageEnglish
Title of host publication10th International Scientific Conference ENGINEERING FOR RURAL DEVELOPMENT
Subtitle of host publicationProceedings
Place of PublicationJelgava
PublisherLatvia University of Agriculture
Pages103-108
Number of pages6
Volume10
Publication statusPublished - 2011
Externally publishedYes
Event10th International Scientific Conference on Engineering for Rural Development - Jelgava, Latvia
Duration: 26 May 201127 May 2011
Conference number: 10
https://dom.lndb.lv/data/obj/749869.html

Publication series

NameEngineering for Rural Development
PublisherLatvia University of Life Sciences and Technologies
ISSN (Print)1691-3043

Conference

Conference10th International Scientific Conference on Engineering for Rural Development
Country/TerritoryLatvia
CityJelgava
Period26/05/1127/05/11
Internet address

Keywords*

  • Biochemical network
  • Ethanol
  • Glycolysis
  • Numerical optimization

Field of Science*

  • 1.4 Chemical sciences
  • 1.6 Biological sciences
  • 2.11 Other engineering and technologies
  • 4.1 Agriculture, Forestry, and Fisheries

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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