Cyclisation of γ-halo-β-ketoesters with aromatic amines and aldehydes in methanol gave novel polysubstituted 3-pyrroline derivatives. A plausible mechanism for the reaction has been proposed. The structures of 1,2,3,4-tetrasubstituted 3-pyrrolines were confirmed by NMR spectroscopy and X-ray crystallography.
- γ-Halo-β- ketoesters
- Nitrogen heterocycles
Field of Science*
- 1.4 Chemical sciences
- 1.1. Scientific article indexed in Web of Science and/or Scopus database