TY - JOUR
T1 - From sweat to hope
T2 - The role of exercise-induced extracellular vesicles in cancer prevention and treatment
AU - Llorente, Alicia
AU - Brokāne, Agnese
AU - Mlynska, Agata
AU - Puurand, Marju
AU - Sagini, Krizia
AU - Folkmane, Signe
AU - Hjorth, Marit
AU - Martin-Gracia, Beatriz
AU - Romero, Silvana
AU - Skorinkina, Diana
AU - Čampa, Mārtiņš
AU - Cešeiko, Rūdolfs
AU - Romanchikova, Nadezhda
AU - Kļaviņa, Aija
AU - Käämbre, Tuuli
AU - Linē, Aija
N1 - Publisher Copyright:
© 2024 The Author(s). Journal of Extracellular Vesicles published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.
PY - 2024/8
Y1 - 2024/8
N2 - The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.
AB - The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.
KW - cancer
KW - EV protein cargo
KW - EV RNA cargo
KW - exercise-induced extracellular vesicles
KW - muscle-derived EVs
KW - physical exercise
UR - http://www.scopus.com/inward/record.url?scp=85202052595&partnerID=8YFLogxK
U2 - 10.1002/jev2.12500
DO - 10.1002/jev2.12500
M3 - Review article
C2 - 39183543
AN - SCOPUS:85202052595
SN - 2001-3078
VL - 13
JO - Journal of Extracellular Vesicles
JF - Journal of Extracellular Vesicles
IS - 8
M1 - e12500
ER -
