Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up

Sintija Strautmane; Arturs Balodis; Agnete Teivāne; Dagnija Grabovska; Edgars  Naudiņš; Daniels  Urbanovics; Edgars Fišermans; Jānis Mednieks; Alīna Flintere-Flinta; Zanda Priede; Andrejs Millers; Maksims Zolovs

doi:10.3390/medicina59061082

Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up

Sintija Strautmane (Coresponding Author), Arturs Balodis, Agnete Teivāne, Dagnija Grabovska, Edgars Naudiņš, Daniels Urbanovics, Edgars Fišermans, Jānis Mednieks, Alīna Flintere-Flinta, Zanda Priede, Andrejs Millers, Maksims Zolovs

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Abstract

Background and Objectives: We aimed to determine the link between brain volumetry
results and functional disability calculated using the Expanded Disability Status Scale (EDSS) among
multiple sclerosis (MS) patients in relation to the provided treatment (disease-modifying therapies
(DMTs)) during a 5-year follow-up period. Materials and Methods: A retrospective cohort study
was performed enrolling 66 consecutive patients with a confirmed diagnosis of MS, predominantly
females (62% (n = 41)). Relapsing–remitting (RR) MS was noted in 92% (n = 61) of patients, with the
rest being patients with secondary progressive (SP) MS. The mean age was 43.3 years (SD 8.3 years).
All patients were evaluated clinically using the EDSS and “FreeSurfer© 7.2.0” radiologically during a
5-year follow-up. Results: A significant increase in patient functional disability was noted, calculated
using the EDSS during a 5-year follow-up. The baseline EDSS ranged between 1 and 6 with a median
of 1.5 (IQR 1.5–2.0), and after 5 years, the EDSS was between 1 and 7, with a median EDSS of 3.0
(IQR 2.4–3.6). Compared with RRMS patients, SPMS patients demonstrated a significant increase in
EDSS score during a 5-year period, with a median EDSS of 2.5 in RRMS patients (IQR 2.0–3.3) and 7.0
(IQR 5.0–7.0) among SPMS patients. Significantly lower brain volumetry results in different brain
areas were found, including cortical, total grey and white matter, p < 0.05. Statistically significant
differences were observed between baseline volumetry results of the hippocampus and the middle
anterior part of the corpus callosum and their volumetry results after 5 years, p < 0.001. In this
study population, the thalamus did not demonstrate significant changes in volumetry results during
follow-up, p > 0.05. The provided treatment (DMTs) did not demonstrate a significant impact on the
brain MRI volumetry results during a 5-year follow-up, p > 0.05. Conclusions: Brain MRI volumetry
seriously impacts the early detection of brain atrophic changes. In this study, significant relationship
between brain magnetic resonance volumetry results and disability progression among MS patients
with no important impact of the provided treatment was described. Brain MRI volumetry may aid
in the identification of early disease progression among MS patients, as well as enrich the clinical
evaluation of MS patients in clinical patient care.

Original language	English
Article number	1082
Number of pages	12
Journal	Medicina
Volume	59
Issue number	6
DOIs	https://doi.org/10.3390/medicina59061082
Publication status	Published - 4 Jun 2023

Keywords*

multiple sclerosis
brain atrophy
MRI
EDSS
disability

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.3390/medicina59061082Licence: CC BY

Functional Disability and Brain MRI VolumetryFinal published version, 1.52 MBLicence: CC BY

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Strautmane, S., Balodis, A., Teivāne, A., Grabovska, D., Naudiņš, E., Urbanovics, D., Fišermans, E., Mednieks, J., Flintere-Flinta, A., Priede, Z., Millers, A., & Zolovs, M. (2023). Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up. Medicina, 59(6), Article 1082. https://doi.org/10.3390/medicina59061082

@article{39692830064d4c6cb13b1e426f9c849a,

title = "Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up",

abstract = "Background and Objectives: We aimed to determine the link between brain volumetryresults and functional disability calculated using the Expanded Disability Status Scale (EDSS) amongmultiple sclerosis (MS) patients in relation to the provided treatment (disease-modifying therapies(DMTs)) during a 5-year follow-up period. Materials and Methods: A retrospective cohort studywas performed enrolling 66 consecutive patients with a confirmed diagnosis of MS, predominantlyfemales (62% (n = 41)). Relapsing–remitting (RR) MS was noted in 92% (n = 61) of patients, with therest being patients with secondary progressive (SP) MS. The mean age was 43.3 years (SD 8.3 years).All patients were evaluated clinically using the EDSS and “FreeSurfer{\textcopyright} 7.2.0” radiologically during a5-year follow-up. Results: A significant increase in patient functional disability was noted, calculatedusing the EDSS during a 5-year follow-up. The baseline EDSS ranged between 1 and 6 with a medianof 1.5 (IQR 1.5–2.0), and after 5 years, the EDSS was between 1 and 7, with a median EDSS of 3.0(IQR 2.4–3.6). Compared with RRMS patients, SPMS patients demonstrated a significant increase inEDSS score during a 5-year period, with a median EDSS of 2.5 in RRMS patients (IQR 2.0–3.3) and 7.0(IQR 5.0–7.0) among SPMS patients. Significantly lower brain volumetry results in different brainareas were found, including cortical, total grey and white matter, p < 0.05. Statistically significantdifferences were observed between baseline volumetry results of the hippocampus and the middleanterior part of the corpus callosum and their volumetry results after 5 years, p < 0.001. In thisstudy population, the thalamus did not demonstrate significant changes in volumetry results duringfollow-up, p > 0.05. The provided treatment (DMTs) did not demonstrate a significant impact on thebrain MRI volumetry results during a 5-year follow-up, p > 0.05. Conclusions: Brain MRI volumetryseriously impacts the early detection of brain atrophic changes. In this study, significant relationshipbetween brain magnetic resonance volumetry results and disability progression among MS patientswith no important impact of the provided treatment was described. Brain MRI volumetry may aidin the identification of early disease progression among MS patients, as well as enrich the clinicalevaluation of MS patients in clinical patient care.",

keywords = "multiple sclerosis, brain atrophy, MRI, EDSS, disability",

author = "Sintija Strautmane and Arturs Balodis and Agnete Teivāne and Dagnija Grabovska and Edgars Naudiņ{\v s} and Daniels Urbanovics and Edgars Fi{\v s}ermans and Jānis Mednieks and Alīna Flintere-Flinta and Zanda Priede and Andrejs Millers and Maksims Zolovs",

note = "Funding Information: This research was funded by the Pauls Stradins Clinical University Hospital Scientific Institute Research Grant. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jun,

day = "4",

doi = "10.3390/medicina59061082",

language = "English",

volume = "59",

journal = "Medicina",

issn = "0025-7680",

publisher = "Instituto de Investigaciones Medicas",

number = "6",

}

TY - JOUR

T1 - Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up

AU - Strautmane, Sintija

AU - Balodis, Arturs

AU - Teivāne, Agnete

AU - Grabovska, Dagnija

AU - Naudiņš, Edgars

AU - Urbanovics, Daniels

AU - Fišermans, Edgars

AU - Mednieks, Jānis

AU - Flintere-Flinta, Alīna

AU - Priede, Zanda

AU - Millers, Andrejs

AU - Zolovs, Maksims

PY - 2023/6/4

Y1 - 2023/6/4

N2 - Background and Objectives: We aimed to determine the link between brain volumetryresults and functional disability calculated using the Expanded Disability Status Scale (EDSS) amongmultiple sclerosis (MS) patients in relation to the provided treatment (disease-modifying therapies(DMTs)) during a 5-year follow-up period. Materials and Methods: A retrospective cohort studywas performed enrolling 66 consecutive patients with a confirmed diagnosis of MS, predominantlyfemales (62% (n = 41)). Relapsing–remitting (RR) MS was noted in 92% (n = 61) of patients, with therest being patients with secondary progressive (SP) MS. The mean age was 43.3 years (SD 8.3 years).All patients were evaluated clinically using the EDSS and “FreeSurfer© 7.2.0” radiologically during a5-year follow-up. Results: A significant increase in patient functional disability was noted, calculatedusing the EDSS during a 5-year follow-up. The baseline EDSS ranged between 1 and 6 with a medianof 1.5 (IQR 1.5–2.0), and after 5 years, the EDSS was between 1 and 7, with a median EDSS of 3.0(IQR 2.4–3.6). Compared with RRMS patients, SPMS patients demonstrated a significant increase inEDSS score during a 5-year period, with a median EDSS of 2.5 in RRMS patients (IQR 2.0–3.3) and 7.0(IQR 5.0–7.0) among SPMS patients. Significantly lower brain volumetry results in different brainareas were found, including cortical, total grey and white matter, p < 0.05. Statistically significantdifferences were observed between baseline volumetry results of the hippocampus and the middleanterior part of the corpus callosum and their volumetry results after 5 years, p < 0.001. In thisstudy population, the thalamus did not demonstrate significant changes in volumetry results duringfollow-up, p > 0.05. The provided treatment (DMTs) did not demonstrate a significant impact on thebrain MRI volumetry results during a 5-year follow-up, p > 0.05. Conclusions: Brain MRI volumetryseriously impacts the early detection of brain atrophic changes. In this study, significant relationshipbetween brain magnetic resonance volumetry results and disability progression among MS patientswith no important impact of the provided treatment was described. Brain MRI volumetry may aidin the identification of early disease progression among MS patients, as well as enrich the clinicalevaluation of MS patients in clinical patient care.

AB - Background and Objectives: We aimed to determine the link between brain volumetryresults and functional disability calculated using the Expanded Disability Status Scale (EDSS) amongmultiple sclerosis (MS) patients in relation to the provided treatment (disease-modifying therapies(DMTs)) during a 5-year follow-up period. Materials and Methods: A retrospective cohort studywas performed enrolling 66 consecutive patients with a confirmed diagnosis of MS, predominantlyfemales (62% (n = 41)). Relapsing–remitting (RR) MS was noted in 92% (n = 61) of patients, with therest being patients with secondary progressive (SP) MS. The mean age was 43.3 years (SD 8.3 years).All patients were evaluated clinically using the EDSS and “FreeSurfer© 7.2.0” radiologically during a5-year follow-up. Results: A significant increase in patient functional disability was noted, calculatedusing the EDSS during a 5-year follow-up. The baseline EDSS ranged between 1 and 6 with a medianof 1.5 (IQR 1.5–2.0), and after 5 years, the EDSS was between 1 and 7, with a median EDSS of 3.0(IQR 2.4–3.6). Compared with RRMS patients, SPMS patients demonstrated a significant increase inEDSS score during a 5-year period, with a median EDSS of 2.5 in RRMS patients (IQR 2.0–3.3) and 7.0(IQR 5.0–7.0) among SPMS patients. Significantly lower brain volumetry results in different brainareas were found, including cortical, total grey and white matter, p < 0.05. Statistically significantdifferences were observed between baseline volumetry results of the hippocampus and the middleanterior part of the corpus callosum and their volumetry results after 5 years, p < 0.001. In thisstudy population, the thalamus did not demonstrate significant changes in volumetry results duringfollow-up, p > 0.05. The provided treatment (DMTs) did not demonstrate a significant impact on thebrain MRI volumetry results during a 5-year follow-up, p > 0.05. Conclusions: Brain MRI volumetryseriously impacts the early detection of brain atrophic changes. In this study, significant relationshipbetween brain magnetic resonance volumetry results and disability progression among MS patientswith no important impact of the provided treatment was described. Brain MRI volumetry may aidin the identification of early disease progression among MS patients, as well as enrich the clinicalevaluation of MS patients in clinical patient care.

KW - multiple sclerosis

KW - brain atrophy

KW - MRI

KW - EDSS

KW - disability

UR - http://www.scopus.com/inward/record.url?scp=85163701468&partnerID=8YFLogxK

U2 - 10.3390/medicina59061082

DO - 10.3390/medicina59061082

M3 - Article

SN - 0025-7680

VL - 59

JO - Medicina

JF - Medicina

IS - 6

M1 - 1082

ER -

Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up

Abstract

Keywords*

Field of Science*

Publication Type*

Access to Document

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Study Findings on Multiple Sclerosis Described by a Researcher at Riga Stradins University (Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up)

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Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up

Abstract

Keywords*

Field of Science*

Publication Type*

Access to Document

Other files and links

Fingerprint

Press/Media

Study Findings on Multiple Sclerosis Described by a Researcher at Riga Stradins University (Functional Disability and Brain MRI Volumetry Results among Multiple Sclerosis Patients during 5-Year Follow-Up)

Cite this