Funktion der isolierten heterogenen Leber bei ihrer Perfusion durch Menschenblut

M. S. Margulis; D. B. Krivulis; R. L. Rosental; G. I. Cimmerman; E. A. Kvizinskaja; A. A. Brence

doi:10.1007/BF01856452

Funktion der isolierten heterogenen Leber bei ihrer Perfusion durch Menschenblut

Translated title of the contribution: The function of the isolated heterologous liver perfused with the human blood

M. S. Margulis, D. B. Krivulis, R. L. Rosental, G. I. Cimmerman, E. A. Kvizinskaja, A. A. Brence

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The metabolic changes and their influence on the isolated liver were studied in 21 experiments on pig liver, perfused with human blood during the period of 3 hrs. It was detected, that rather active carbohydrate and nitrogenic metabolism has been maintained in the liver during 1.5-2 hrs. But after the 2nd hr of perfusion the phenomens of perfusion the phenomens of hypoxia increased, that caused the inhibition of metabolic processes and leaded to deterioration of liver function. The experience of clinical perfusions showed, that the functional activity of assisted liver over the period of 90 min was so depressed, that the organ couldn't provide positive clinical effect.

Translated title of the contribution	The function of the isolated heterologous liver perfused with the human blood
Original language	German
Pages (from-to)	75-78
Number of pages	4
Journal	Research in Experimental Medicine
Volume	165
Issue number	1
DOIs	https://doi.org/10.1007/BF01856452
Publication status	Published - Feb 1975
Externally published	Yes

Keywords*

Heterologous liver perfusion
Liver conservation
Liver metabolism
Pig liver
Temporary liver substitution

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1007/BF01856452

Cite this

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title = "Funktion der isolierten heterogenen Leber bei ihrer Perfusion durch Menschenblut",

abstract = "The metabolic changes and their influence on the isolated liver were studied in 21 experiments on pig liver, perfused with human blood during the period of 3 hrs. It was detected, that rather active carbohydrate and nitrogenic metabolism has been maintained in the liver during 1.5-2 hrs. But after the 2nd hr of perfusion the phenomens of perfusion the phenomens of hypoxia increased, that caused the inhibition of metabolic processes and leaded to deterioration of liver function. The experience of clinical perfusions showed, that the functional activity of assisted liver over the period of 90 min was so depressed, that the organ couldn't provide positive clinical effect.",

keywords = "Heterologous liver perfusion, Liver conservation, Liver metabolism, Pig liver, Temporary liver substitution",

author = "Margulis, {M. S.} and Krivulis, {D. B.} and Rosental, {R. L.} and Cimmerman, {G. I.} and Kvizinskaja, {E. A.} and Brence, {A. A.}",

year = "1975",

month = feb,

doi = "10.1007/BF01856452",

language = "German",

volume = "165",

pages = "75--78",

journal = "Research in Experimental Medicine",

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T1 - Funktion der isolierten heterogenen Leber bei ihrer Perfusion durch Menschenblut

AU - Margulis, M. S.

AU - Krivulis, D. B.

AU - Rosental, R. L.

AU - Cimmerman, G. I.

AU - Kvizinskaja, E. A.

AU - Brence, A. A.

PY - 1975/2

Y1 - 1975/2

N2 - The metabolic changes and their influence on the isolated liver were studied in 21 experiments on pig liver, perfused with human blood during the period of 3 hrs. It was detected, that rather active carbohydrate and nitrogenic metabolism has been maintained in the liver during 1.5-2 hrs. But after the 2nd hr of perfusion the phenomens of perfusion the phenomens of hypoxia increased, that caused the inhibition of metabolic processes and leaded to deterioration of liver function. The experience of clinical perfusions showed, that the functional activity of assisted liver over the period of 90 min was so depressed, that the organ couldn't provide positive clinical effect.

AB - The metabolic changes and their influence on the isolated liver were studied in 21 experiments on pig liver, perfused with human blood during the period of 3 hrs. It was detected, that rather active carbohydrate and nitrogenic metabolism has been maintained in the liver during 1.5-2 hrs. But after the 2nd hr of perfusion the phenomens of perfusion the phenomens of hypoxia increased, that caused the inhibition of metabolic processes and leaded to deterioration of liver function. The experience of clinical perfusions showed, that the functional activity of assisted liver over the period of 90 min was so depressed, that the organ couldn't provide positive clinical effect.

KW - Heterologous liver perfusion

KW - Liver conservation

KW - Liver metabolism

KW - Pig liver

KW - Temporary liver substitution

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U2 - 10.1007/BF01856452

DO - 10.1007/BF01856452

M3 - Article

C2 - 1138321

AN - SCOPUS:0016694478

SN - 0300-9130

VL - 165

SP - 75

EP - 78

JO - Research in Experimental Medicine

JF - Research in Experimental Medicine

IS - 1

ER -

Funktion der isolierten heterogenen Leber bei ihrer Perfusion durch Menschenblut

Abstract

Keywords*

Field of Science*

Publication Type*

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