Fused Deposition Modelling 3D Printed Immediate Release Tablets – Understanding the Impact of Printer Parameters

Z. Zhang; Valentyn Mohylyuk; S. Li; D. S. Jones; G. P.  Andrews

doi:10.5920/bjpharm.1159

Fused Deposition Modelling 3D Printed Immediate Release Tablets – Understanding the Impact of Printer Parameters

Z. Zhang
, Valentyn Mohylyuk
, S. Li
, D. S. Jones
, G. P. Andrews (Corresponding Author)

Research output: Contribution to journal › Conference article › peer-review

Abstract

The aim of this study was to prepare tablets that offer an immediate release (IR) of the loaded active ingredient using fused deposition modelling (FDM) 3D printing. Hydrochlorothiazide (HCTZ) was used as a model drug, with polyvinyl alcohol (PVA) as the primary polymeric carrier and sorbitol as a plasticizer. The impact of printer parameters, including infill density, roof and floor (R&F) thickness and nozzle size, on the drug release properties of printed tablets was investigated. The results support the use of FDM-3DP as an approach to manufacture IR tablets and highlighted the importance of the printing design on drug release properties.

Original language	English
Article number	1159
Journal	British Journal of Pharmacy
Volume	7
Issue number	2
DOIs	https://doi.org/10.5920/bjpharm.1159
Publication status	Published - 2022
Externally published	Yes
Event	13th Conference of Academy of Pharmaceutical Sciences (APS) - Belfast, United Kingdom Duration: 7 Sept 2022 → 9 Sept 2022 Conference number: 13 https://www.emedevents.com/c/medical-conferences-2022/13th-academy-of-pharmaceutical-sciences-aps-pharmsci-international-conferance-2022

Field of Science*

3.1 Basic medicine

Publication Type*

1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)

Access to Document

10.5920/bjpharm.1159Licence: CC BY

1 Review article

PEEK Implants for Cranioplasty: A Mapping Review of 3D Printing, Surface Functionalisation, and Clinical Performance Gaps
Horvath, Z. M., Viter, R., Radziņš, O., Thor, A., Kolisnyk, T. & Mohylyuk, V. (Corresponding Author), 27 Apr 2026, In: Materials Advances. 7, 8, p. 3935-3958
Research output: Contribution to journal › Review article › peer-review

Open Access

1 Hosting an academic visitor
1 Poster presentation

Drug Release Individualisation from FDM 3D-Printed Oral Dosage Form of Prednisolone
Horvath, Z. M. (Speaker), Grundsteins , K. (Co-author), Radziņš, O. (Co-author), Kons, A. (Co-author), Bērziņš, A. (Co-author), Viter, R. (Co-author), Lamprou, D. A. (Co-author) & Mohylyuk, V. (Co-author)
26 Mar 2025 → 28 Mar 2025
Activity: Talk or presentation types › Poster presentation
Karlis Grundsteins
Mohylyuk, V. (Host)
1 Nov 2024
Activity: Hosting a visitor types › Hosting an academic visitor

Cite this

@article{9466732fd41f489887ab66b28fbfec6c,

title = "Fused Deposition Modelling 3D Printed Immediate Release Tablets – Understanding the Impact of Printer Parameters",

abstract = "The aim of this study was to prepare tablets that offer an immediate release (IR) of the loaded active ingredient using fused deposition modelling (FDM) 3D printing. Hydrochlorothiazide (HCTZ) was used as a model drug, with polyvinyl alcohol (PVA) as the primary polymeric carrier and sorbitol as a plasticizer. The impact of printer parameters, including infill density, roof and floor (R\&F) thickness and nozzle size, on the drug release properties of printed tablets was investigated. The results support the use of FDM-3DP as an approach to manufacture IR tablets and highlighted the importance of the printing design on drug release properties.",

author = "Z. Zhang and Valentyn Mohylyuk and S. Li and Jones, \{D. S.\} and Andrews, \{G. P.\}",

year = "2022",

doi = "10.5920/bjpharm.1159",

language = "English",

volume = "7",

journal = "British Journal of Pharmacy",

issn = "2058-8356",

publisher = "University of Huddersfield Press",

number = "2",

note = "13th Conference of Academy of Pharmaceutical Sciences (APS) , PharmSci International Conference 2022 ; Conference date: 07-09-2022 Through 09-09-2022",

url = "https://www.emedevents.com/c/medical-conferences-2022/13th-academy-of-pharmaceutical-sciences-aps-pharmsci-international-conferance-2022",

}

TY - JOUR

T1 - Fused Deposition Modelling 3D Printed Immediate Release Tablets – Understanding the Impact of Printer Parameters

AU - Zhang, Z.

AU - Mohylyuk, Valentyn

AU - Li, S.

AU - Jones , D. S.

AU - Andrews, G. P.

N1 - Conference code: 13

PY - 2022

Y1 - 2022

N2 - The aim of this study was to prepare tablets that offer an immediate release (IR) of the loaded active ingredient using fused deposition modelling (FDM) 3D printing. Hydrochlorothiazide (HCTZ) was used as a model drug, with polyvinyl alcohol (PVA) as the primary polymeric carrier and sorbitol as a plasticizer. The impact of printer parameters, including infill density, roof and floor (R&F) thickness and nozzle size, on the drug release properties of printed tablets was investigated. The results support the use of FDM-3DP as an approach to manufacture IR tablets and highlighted the importance of the printing design on drug release properties.

AB - The aim of this study was to prepare tablets that offer an immediate release (IR) of the loaded active ingredient using fused deposition modelling (FDM) 3D printing. Hydrochlorothiazide (HCTZ) was used as a model drug, with polyvinyl alcohol (PVA) as the primary polymeric carrier and sorbitol as a plasticizer. The impact of printer parameters, including infill density, roof and floor (R&F) thickness and nozzle size, on the drug release properties of printed tablets was investigated. The results support the use of FDM-3DP as an approach to manufacture IR tablets and highlighted the importance of the printing design on drug release properties.

U2 - 10.5920/bjpharm.1159

DO - 10.5920/bjpharm.1159

M3 - Conference article

SN - 2058-8356

VL - 7

JO - British Journal of Pharmacy

JF - British Journal of Pharmacy

IS - 2

M1 - 1159

T2 - 13th Conference of Academy of Pharmaceutical Sciences (APS)

Y2 - 7 September 2022 through 9 September 2022

ER -

Fused Deposition Modelling 3D Printed Immediate Release Tablets – Understanding the Impact of Printer Parameters

Abstract

Field of Science*

Publication Type*

Access to Document

Fingerprint

Research output

PEEK Implants for Cranioplasty: A Mapping Review of 3D Printing, Surface Functionalisation, and Clinical Performance Gaps

Activities

Drug Release Individualisation from FDM 3D-Printed Oral Dosage Form of Prednisolone

Karlis Grundsteins

Cite this