GADOLINIUM RETENTION IN PEDIATRIC BRAIN: HYPERINTENSITY IN NUCLEUS DENTATUS AND GLOBUS PALLIDUS; WHEN IT APPEARS?

Reinis Pitura, Gaida Krūmiņa, Dāvis Sosārs, Ilze Apine

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Introduction
Currently, there is no proof of clinical neuronal damage caused by
Gadolinium deposits however the risk still persists, especially in
pediatrics due to longer life expectancy. By determining after how many
contras-MR examinations these deposits become obvious could point out
the patients at highest risk and need for future observation.
Methods
Retrospective study performed at Children's Clinical University hospital
included 37 pediatric patients (26 oncologic; 11 with other brain pathologies) with mean age 7.8 who received six or more post contrast head MRI
with Gadodiamide. 193 subsequent pre-contrast MRI series were used for
analysis. The regions of interest were pathology-free. The first examination
was used as a reference. Other groups (Reference,1,2,3,4,5) were labeled
based on serial number of contrast-MRI. Data were obtained from patient's
medical records and radiological server. Signal intensity measurements
were performed in axial pre-cT1wFFE images. Region of interest was
10mm2 in four localizations: dentate nucleus (DN), globus pallidus (GP),
pulvinar (TH) and pons (P), on the left side, Measurements were done by
the same investigator repeatedly two times with 2-month interval. Mean
DN:P and GP:TH ratios were calculated from both repetitions and compared with reference group using Wilcoxon signed rank test on SPSS 20.0.
Result
Statistically significant difference was found in both ratios (GP:TH;
DN:P) between the reference and study group 4 (p=0.037; p=0.016)
and study group 5 (p>0.001; p=0.017) with a confidence interval 95%.
Discussion & Conclusion
A significant change in GP: TH and DN:P ratios show that Gd deposits in
globus pallidus and nucleus dentatus can be found in pediatric brain after
the fourth Gd contrast MRI, suggesting that patients with at least 4 MRI
with Gd are potentially in the risk of neuronal damage and development
of neurological symptoms during their lives time until proven otherwise.
Original languageEnglish
PagesS56
Number of pages1
Publication statusPublished - 7 Aug 2019
Event42nd Annual Meeting of the European Society of Neuroradiology – Diagnostic and Interventional - Oslo, Norway
Duration: 18 Sep 201922 Sep 2019
https://www.esnr.org/en/42nd-esnr-annual-meeting/

Meeting

Meeting42nd Annual Meeting of the European Society of Neuroradiology – Diagnostic and Interventional
Country/TerritoryNorway
CityOslo
Period18/09/1922/09/19
Internet address

Field of Science*

  • 3.3 Health sciences

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)

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