Gastric plasma biomarkers and Operative Link for Gastritis Assessment gastritis stage

Ilva Daugule, Agnese Sudraba, Han Mo Chiu, Konrads Funka, Audrius Ivanauskas, Dainius Janciauskas, Laimas Jonaitis, Gediminas Kiudelis, Ivars Tolmanis, Aigars Vanags, Jaw Town Lin, Limas Kupcinskas, Marcis Leja

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


INTRODUCTION: The Operative Link for Gastritis Assessment (OLGA) staging system has been proposed as a histopathological reporting system of gastric atrophy. Noninvasive methods for indirect evaluation of gastric mucosal atrophy by biomarkers are also being introduced. OBJECTIVES: To analyze gastric mucosal atrophy by biomarkers, pepsinogen I (PgI), pepsinogen II (PgII), PgI/PgII ratio, fasting gastrin-17 (G-17), stimulated gastrin-17 (sG-17), in relation to OLGA gastritis stage. PATIENTS AND METHODS: Gastric biopsies were taken from 269 prospective patients referred for upper endoscopy because of dyspeptic problems and evaluated by two expert pathologists (D.J. and P.S.). Atrophy was assessed according to the OLGA staging system. Pg I, PgII, Pg I/II, G-17, sG-17 were determined in a plasma sample. RESULTS: The mean levels of PgI and PgI/PgII decreased significantly from 90.8 μg/l and 7.6 in stage 0 gastritis to 64.3 μg/l and 4.3 in high-stage gastritis. The mean values of G-17 and sG-17 were significantly higher among patients with stage II gastritis compared with stage 0 and high-stage gastritis.The proportion of patients with normal mucosa and nonatrophic gastritis according to biomarkers decreased from 78% in stage 0 to 22% in high-stage (III-IV) gastritis. Among the latter no case with normal mucosa, according to biomarkers, was observed. CONCLUSIONS: A significant inverse correlation between the mean levels of PgI, PgI/II ratio and the OLGA stage was observed. Percentage of dyspeptic patients with normal mucosa, by blood biomarkers, decreased with increasing OLGA gastritis stages. OLGA staging system provides a good frame for scientific analysis of gastric mucosal atrophy.

Original languageEnglish
Pages (from-to)302-307
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number4
Publication statusPublished - Apr 2011
Externally publishedYes


  • gastric atrophy
  • gastric biomarkers
  • Operative Link for Gastritis Assessment gastritis stage

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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