Motivating clinically healthy overweight and obese individuals to bring lifestyle behavioural changes need adequate knowledge of risk factors in an individual. Non-alcoholic fatty liver disease (NAFLD) is considered a significant cardiovascular diseases (CVD) risk factor. Screening for NAFLD in overweight and obese individuals and implementing early lifestyle changes could reduce the incidence of CVD. Sex, body mass index (BMI), waist, insulin resistance index (HOMAIR) and atherogenic index (TC/HDL-C ratio) are widely used for CVD risk screening, however their predictive value regarding NAFLD is not unambiguous
Which of following CVD risk indicators (sex, BMI, waist, HOMAIR and TC/HDL-C ratio) could be used for prediction NAFLD in Latvian overweight and obese individuals?
A cross sectional survey of 30 to 45 years old clinically healthy men (N=31, age 36,4±4,0, BMI 32,8±4,0) and women (N=60, age 37,1±4,2, BMI 32,0±4,5) having body mass index ≥25 m2/kg was conducted in Riga, Latvia. Gender related differences of waist, HOMA-IR, TC/HDL-C ratio and hepatic density (HD) (NAFLD indicator on CT scan) were estimated using Mann-Whitney U test, as well as correlations of hepatic density with other CVD risk factors were calculated as Spearman’s rho. Logistic regression model was used to estimate predictive value of CVD risk factors regarding NAFLD.
We found that men compared to women had significantly increased waist circumference (107,8±10,8 and 95,7±10,5 respectively; p<0,001), TC/HDL-C (4,9±0,8 and 3,5±1,1 respectively; p<0,001) and decreased HD (50,0±0,8 and 57,0±7,6 respectively; p<0,001). There was no significant difference regarding HOMA-IR (3,5±1,8 in men and 3,0±1,7 in women). In the whole group HD negatively correlated with BMI (r=-0,316, p=0,002), waist (r=-0,467, p<0,001), TC/HDL-C (r=-0,287, p=0,006) and HOMA-IR (r=-0,277, p=0,008). Binary logistic regression model including sex, waist, HOMA-IR and TC/HDL-C, however, showed that only male gender increases NAFLD risk (Exp(B)=5,310, p=0,014).
BMI, waist, HOMAIR and TC/HDL-C ratio negatively correlate with hepatic density, however, only male sex could be considered as a NAFLD predictor in overweight and obese individuals residing in Riga.
Points for discussion
Which tests should be most appropriate for NAFLD screening?
|Number of pages||1|
|Publication status||Published - 2013|
|Event||18th Nordic Congress of General Practice (NCGP): Promoting partnership with our patients – a challenge and a chance for primary care - Tampere, Finland|
Duration: 21 Aug 2013 → 24 Aug 2013
Conference number: 18
|Congress||18th Nordic Congress of General Practice (NCGP)|
|Abbreviated title||NCGP 2013|
|Period||21/08/13 → 24/08/13|
Field of Science*
- 3.2 Clinical medicine
- 3.4. Other publications in conference proceedings (including local)