TY - JOUR
T1 - General influence of biphasic calcium phosphate on osteoporotic bone density
AU - Ananjevs, Vladislavs
AU - Ananjeva, Aleksandra
AU - Vetra, Janis
AU - Skagers, Andrejs
AU - Salma, Ilze
AU - Neimane, Laura
AU - Kasyanov, Vladimir
N1 - Funding Information:
The study was supported by the National Research Programme No. 2014.10-4/VPP-3/21 “Multifunctional Components and composites, photonics and nanotechnology”. Project No. 4 “Nanocomponents and nanotechnologies for medical applications”.
Publisher Copyright:
© 2019 Vladislavs Ananjevs et al., published by Sciendo 2019.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.
AB - Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.
KW - biphasic calcium phosphate
KW - bone density
KW - in vivo
KW - osteoporosis
KW - strontium
UR - http://www.scopus.com/inward/record.url?scp=85065676218&partnerID=8YFLogxK
U2 - 10.2478/prolas-2019-0029
DO - 10.2478/prolas-2019-0029
M3 - Article
AN - SCOPUS:85065676218
SN - 1407-009X
VL - 73
SP - 185
EP - 188
JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
IS - 2
ER -