General influence of biphasic calcium phosphate on osteoporotic bone density

Vladislavs Ananjevs, Aleksandra Ananjeva, Janis Vetra, Andrejs Skagers, Ilze Salma, Laura Neimane, Vladimir Kasyanov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Issue number2
Publication statusPublished - 1 May 2019


  • biphasic calcium phosphate
  • bone density
  • in vivo
  • osteoporosis
  • strontium

Field of Science*

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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