General methods for the synthesis of styrylpyridinium salts (microreview)

Reinis Putrālis (Corresponding Author), Aiva Plotniece, Karlis Pajuste

Research output: Contribution to journalArticlepeer-review

Abstract

This microreview covers the general methods on the synthesis of mono-, bis-, and tristyrylpyridinium fluorophores described in the literature in recent years. A summary of the most common synthesis can be divided into four distinct methods: aldol condensation followed by N-alkylation of pyridine moiety, Knoevenagel condensation reaction of picolinium salt and aldehyde, Wittig reaction of triphenylphosphine salt and pyridine aldehyde followed by N-alkylation of pyridine moiety, and Horner reaction between bisphosphonate derivative and 4-pyridinecarboxaldehyde followed by N-alkylation of pyridine moiety. Metal-catalyzed reactions were not reviewed. The microreview primary focuses on the synthesis of styrylpyridinium salts having in their structures a 4-pyridinium moiety. 

Original languageEnglish
Article number117377
JournalChemistry of Heterocyclic Compounds
DOIs
Publication statusE-pub ahead of print - Jan 2025

Field of Science*

  • 1.4 Chemical sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'General methods for the synthesis of styrylpyridinium salts (microreview)'. Together they form a unique fingerprint.

Cite this