Genetic alteration in melanoma development

Dace Pjanova; Kristīne Azarjana; Ingrida Čema; Olita Heisele

doi:10.2478/v10046-009-0029-2

Genetic alteration in melanoma development

Dace Pjanova, Kristīne Azarjana, Ingrida Čema, Olita Heisele

Rīga Stradiņš University

Research output: Contribution to journal › Review article › peer-review

6 Downloads (Pure)

Abstract

The transition from a normal to a neoplastic cell is a complex process and involves many sequential genetic events. Over the last several years, substantial progress has been made in the understanding of molecular biology of melanoma including its development, progression, and resistance to therapy. An important step in cancer development appears to be senescence - a crucial barrier that prevents the proliferation of cells that are at different stages of malignancy. This review is mainly focused on patterns of molecular changes in the different steps of neoplastic transformation in melanoma and provides an up-to-date view on our understanding of the molecular genetics of melanoma development as well as therapeutic approaches based on this knowledge.

Original language	English
Pages (from-to)	73-80
Number of pages	8
Journal	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume	63
Issue number	3
DOIs	https://doi.org/10.2478/v10046-009-0029-2
Publication status	Published - 2009

Keywords*

Cancer
Genes
Genetics
Melanoma
Mutations

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2478/v10046-009-0029-2

Genetic alteration in melanoma developmentFinal published version, 187 KB

Cite this

@article{8c25e555dba6445dbfe15c17ccecb507,

title = "Genetic alteration in melanoma development",

abstract = "The transition from a normal to a neoplastic cell is a complex process and involves many sequential genetic events. Over the last several years, substantial progress has been made in the understanding of molecular biology of melanoma including its development, progression, and resistance to therapy. An important step in cancer development appears to be senescence - a crucial barrier that prevents the proliferation of cells that are at different stages of malignancy. This review is mainly focused on patterns of molecular changes in the different steps of neoplastic transformation in melanoma and provides an up-to-date view on our understanding of the molecular genetics of melanoma development as well as therapeutic approaches based on this knowledge.",

keywords = "Cancer, Genes, Genetics, Melanoma, Mutations",

author = "Dace Pjanova and Kristīne Azarjana and Ingrida {\v C}ema and Olita Heisele",

note = "Funding Information: We acknowledge a grant from the European Social Fund (ESF) programme No. ESS2004/3.",

year = "2009",

doi = "10.2478/v10046-009-0029-2",

language = "English",

volume = "63",

pages = "73--80",

journal = "Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences",

issn = "1407-009X",

publisher = "de Gruyter",

number = "3",

}

TY - JOUR

T1 - Genetic alteration in melanoma development

AU - Pjanova, Dace

AU - Azarjana, Kristīne

AU - Čema, Ingrida

AU - Heisele, Olita

N1 - Funding Information: We acknowledge a grant from the European Social Fund (ESF) programme No. ESS2004/3.

PY - 2009

Y1 - 2009

N2 - The transition from a normal to a neoplastic cell is a complex process and involves many sequential genetic events. Over the last several years, substantial progress has been made in the understanding of molecular biology of melanoma including its development, progression, and resistance to therapy. An important step in cancer development appears to be senescence - a crucial barrier that prevents the proliferation of cells that are at different stages of malignancy. This review is mainly focused on patterns of molecular changes in the different steps of neoplastic transformation in melanoma and provides an up-to-date view on our understanding of the molecular genetics of melanoma development as well as therapeutic approaches based on this knowledge.

AB - The transition from a normal to a neoplastic cell is a complex process and involves many sequential genetic events. Over the last several years, substantial progress has been made in the understanding of molecular biology of melanoma including its development, progression, and resistance to therapy. An important step in cancer development appears to be senescence - a crucial barrier that prevents the proliferation of cells that are at different stages of malignancy. This review is mainly focused on patterns of molecular changes in the different steps of neoplastic transformation in melanoma and provides an up-to-date view on our understanding of the molecular genetics of melanoma development as well as therapeutic approaches based on this knowledge.

KW - Cancer

KW - Genes

KW - Genetics

KW - Melanoma

KW - Mutations

UR - http://www.scopus.com/inward/record.url?scp=72849109854&partnerID=8YFLogxK

U2 - 10.2478/v10046-009-0029-2

DO - 10.2478/v10046-009-0029-2

M3 - Review article

AN - SCOPUS:72849109854

SN - 1407-009X

VL - 63

SP - 73

EP - 80

JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 3

ER -

Genetic alteration in melanoma development

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this