Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives: A brief review

Elina Leonova, Nadezhda Ryabokon, Evita Rostoka, Vitalijs Borisovs, Astrida Velena, Egils Bisenieks, Gunars Duburs, Maija Dzintare, Roza Goncharova, Nikolajs Sjakste (Corresponding Author)

Research output: Contribution to journalReview articlepeer-review

Abstract

This review summarises current knowledge about the genotoxic and genoprotective effects of 1,4-dihydropyridines (DHP) with the main focus on the water-soluble 1,4-DHPs. Most of these water-soluble compounds manifest very low calcium channel blocking activity, which is considered "unusual"for 1,4-DHPs. Glutapyrone, diludine, and AV-153 decrease spontaneous mutagenesis and frequency of mutations induced by chemical mutagens. AV-153, glutapyrone, and carbatones protect DNA against the damage produced by hydrogen peroxide, radiation, and peroxynitrite. The ability of these molecules to bind to the DNA may not be the only mechanism of DNA protection, as other mechanisms such as radical scavenging or binding to other genotoxic compounds may take place and enhance DNA repair. These uncertainties and reports of high 1,4-DHP concentrations damaging the DNA call for further in vitro and in vivo preclinical research, pharmacokinetic in particular, as it can help pinpoint the exact mechanism(s) of the genotoxic and/or genoprotective action of 1,4-DHPs.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalArhiv za Higijenu Rada i Toksikologiju
Volume74
Issue number1
DOIs
Publication statusPublished - 1 Mar 2023

Keywords*

  • 1
  • 4-DHP
  • AV-153
  • carbatones
  • diludine
  • DNA binding
  • glutapyrone

Field of Science*

  • 3.1 Basic medicine
  • 1.4 Chemical sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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