TY - JOUR
T1 - Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives
T2 - A brief review
AU - Leonova, Elina
AU - Ryabokon, Nadezhda
AU - Rostoka, Evita
AU - Borisovs, Vitalijs
AU - Velena, Astrida
AU - Bisenieks, Egils
AU - Duburs, Gunars
AU - Dzintare, Maija
AU - Goncharova, Roza
AU - Sjakste, Nikolajs
N1 - Publisher Copyright:
© 2023 Elina Leonova et al., published by Sciendo.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - This review summarises current knowledge about the genotoxic and genoprotective effects of 1,4-dihydropyridines (DHP) with the main focus on the water-soluble 1,4-DHPs. Most of these water-soluble compounds manifest very low calcium channel blocking activity, which is considered "unusual"for 1,4-DHPs. Glutapyrone, diludine, and AV-153 decrease spontaneous mutagenesis and frequency of mutations induced by chemical mutagens. AV-153, glutapyrone, and carbatones protect DNA against the damage produced by hydrogen peroxide, radiation, and peroxynitrite. The ability of these molecules to bind to the DNA may not be the only mechanism of DNA protection, as other mechanisms such as radical scavenging or binding to other genotoxic compounds may take place and enhance DNA repair. These uncertainties and reports of high 1,4-DHP concentrations damaging the DNA call for further in vitro and in vivo preclinical research, pharmacokinetic in particular, as it can help pinpoint the exact mechanism(s) of the genotoxic and/or genoprotective action of 1,4-DHPs.
AB - This review summarises current knowledge about the genotoxic and genoprotective effects of 1,4-dihydropyridines (DHP) with the main focus on the water-soluble 1,4-DHPs. Most of these water-soluble compounds manifest very low calcium channel blocking activity, which is considered "unusual"for 1,4-DHPs. Glutapyrone, diludine, and AV-153 decrease spontaneous mutagenesis and frequency of mutations induced by chemical mutagens. AV-153, glutapyrone, and carbatones protect DNA against the damage produced by hydrogen peroxide, radiation, and peroxynitrite. The ability of these molecules to bind to the DNA may not be the only mechanism of DNA protection, as other mechanisms such as radical scavenging or binding to other genotoxic compounds may take place and enhance DNA repair. These uncertainties and reports of high 1,4-DHP concentrations damaging the DNA call for further in vitro and in vivo preclinical research, pharmacokinetic in particular, as it can help pinpoint the exact mechanism(s) of the genotoxic and/or genoprotective action of 1,4-DHPs.
KW - 1
KW - 4-DHP
KW - AV-153
KW - carbatones
KW - diludine
KW - DNA binding
KW - glutapyrone
UR - http://www.scopus.com/inward/record.url?scp=85151787603&partnerID=8YFLogxK
U2 - 10.2478/aiht-2023-74-3707
DO - 10.2478/aiht-2023-74-3707
M3 - Review article
C2 - 37014687
AN - SCOPUS:85151787603
SN - 0004-1254
VL - 74
SP - 1
EP - 7
JO - Arhiv za Higijenu Rada i Toksikologiju
JF - Arhiv za Higijenu Rada i Toksikologiju
IS - 1
ER -