Abstract
The evaluation of the effect of SARS-CoV-2 infection during pregnancy has raised interest. Even if virus vertical transmission is still controversial, several researchers have focused on the possible distinctive markers associated with different susceptibility to SARS-CoV-2 infection during pregnancy. Morphological alterations were assessed in the placental / chorionic villi,chorionic plate, basal plate, and umbilical cord tissues obtained from 7 subjects with symptomatic respiratory SARS-CoV-2 infection and compared with those in 7 non-COVID control subjects. The expression of SARS-CoV-2 Nucleoprotein (NP) and Human Leukocyte Antigen-G (HLA-G) was estimated by the use of immunohistochemistry. The 57%, 42,8%, and 28,6% of placental / chorionic villi, chorionic plate, and basal plate, respectively, were found positive for NP antigen (p<0.01), while none of the umbilical cords stained for NP. Placental / chorionic villi samples showed the highest positivity for NP. The presence of NP positivity correlated with high levels of the fibrinoid component in placental / chorionic villi samples and leukocyte infiltration in basal plate. All placental / chorionic villi samples were found positive for HLA-G, independently from NP staining. All the NP positive chorionic plate and half of the NP positive basal plate samples expressed HLA-G. On the contrary, the placental / chorionic villi, chorionic plate, and basal plate of all non-COVID subjects were positive for HLA-G, with a higher H-score in comparison to pathological samples (p<0.05). The presence of SARS-CoV-2 NP expression in gestational tissues correlates with morphological alterations and a decreased HLA-G expression compared to the ontrol group. These data suggest a possible implication of SARS-CoV-2 infection in morphological and protein expression modification during pregnancy, which might impact on infection susceptibility, pregnancy complications, and vertical transmission.
Original language | English |
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Pages | 24-24 |
Number of pages | 1 |
Publication status | Published - 2023 |
Event | 2nd Conference of the World Sociey for Virology (WSV): One Health - One World-One Virology - Riga Stradiņš University, Dzirciema St. 16, Riga, Latvia Duration: 15 Jun 2023 → 17 Jun 2023 Conference number: 2 https://www.wsv2023.com/event-details/wsv2023-conference-1 https://www.wsv2023.com/ https://www.wsv2023.com/full-program |
Conference
Conference | 2nd Conference of the World Sociey for Virology (WSV) |
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Abbreviated title | WSV2023 |
Country/Territory | Latvia |
City | Riga |
Period | 15/06/23 → 17/06/23 |
Internet address |
Keywords*
- Covid-19
- pregnancy
- HLA-G
- immunohistochemistry
Field of Science*
- 3.1 Basic medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)